A retinoic acid-triggered cascade of HOXB1 gene activation

Toshihiko Ogura, Ronald M. Evans

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)


Retinoic acid (RA) has been proposed to be a direct regulator of HOX gene complexes. However, the molecular mechanism of the RA signaling pathway during normal development is unclear. We have identified an RA-responsive element in the promoter of HOXB1 gene composed of two functionally separable sites: (i) a DR-2 sequence, which is the direct target of the RA receptor·retinoid X receptor heterodimer; and (ii) a motif for an RA- inducible and tissue-specific coactivator termed retinoid-inducible protein. Though neither enhancer alone is functional, this combined element strongly activates the HOXB1 promoter in a cell-specific and retinoid-dependent manner. Finally, this activation is potentiated by a proximal autoregulatory site for HOXB1 gene itself. These data define a tripartite cascade leading to the establishment of HOXB1 gene activation.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number2
Publication statusPublished - 1995 Jan 17


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