@article{743e9da22e5d469fa6610ced9ad6bc15,
title = "A single meal has the potential to alter brain oxylipin content",
abstract = "Our objective was to determine whether consumption of a single meal has the potential to alter brain oxylipin content. We examined the cerebrum of mice fed a single high-fat/high-sucrose Western meal or a low-fat/low-sucrose control meal, as well as fasted mice. We found no changes in fatty acid composition of cerebrum across the groups. The cerebral oxylipin profile of mice fed a Western meal is distinct from the profile of mice fed a low-fat/low-sucrose meal. Cerebral gene expression of cyclooxygenase 1, cyclooxygenase 2, and epoxide hydrolase 1 were elevated in Western meal-fed mice compared to low-fat/low-sucrose meal-fed mice. Mice that consumed either meal had lower gene expression of cytochrome P450, family 2, subfamily j, polypeptide 12 than fasted mice. Our data in this hypothesis-generating study indicates that the composition of a single meal has the potential to alter brain oxylipins and the gene expression of the enzymes responsible for their production.",
keywords = "Brain, Fasting, Fatty acids, Meal consumption, Oxylipins, Western diet",
author = "Norman, {J. E.} and Aung, {H. H.} and Y. Otoki and Z. Zhang and Taha, {A. Y.} and Rutledge, {J. C.}",
note = "Funding Information: The work in this study was supported by the Nora Eccles Treadwell Foundation through the Cardiovascular, metabolic, and sex effects on cognitive function award (J.C. Rutledge and A.C. Villablanca), the Richard A. and Nora Eccles Harrison Endowed Chair in Diabetes Research Fund (J.C. Rutledge), the Establishment of international agricultural immunology research-core for a quantum improvement in food safety (Japan Society for the Promotion of Science Core-to-Core Program - Advanced Research Networks), the Hellman Family Foundation (A.Y. Taha) and the National Institutes of Health through the following grants: National Institute on Aging R01 AG045541 (J.C. Rutledge) and P30 AG010129 (A.Y. Taha), National Institute of Diabetes and Digestive and Kidney Diseases U24 DK092993–05S1 (J.C. Rutledge) and U24 DK092993 (K. Lloyd). The authors would also like to acknowledge the use of resources provided by the UC Davis Clinical and Translational Sciences Center, funded by the National Center for Advancing Translational Sciences UL1 TR000002 (L.F. Berglund) and UL1 TR001860 (L.F. Berglund). The content of this publication is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or other funding agencies. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2020",
month = mar,
doi = "10.1016/j.plefa.2020.102062",
language = "English",
volume = "154",
journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",
issn = "0952-3278",
publisher = "Churchill Livingstone",
}