A study of periventricular hyperintensity. I. Normal brain aging

Kenichi Meguro, Yasuyoshi Sekita, Tatsuo Yamaguchi, Kenji Yamada, Takashi Hishinuma, Taiju Matsuzawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Fifty-two patients with cerebrovascular risk factors without neurological abnormalities were examined by magnetic resonance imaging and were evaluated for their periventricular hyperintensity (PVH) on T2-weighted images. We assumed that PVH was not a mere focal finding of the brain but a kind of marker for condition related to arteriosclerosis and cerebral ischemia, and we tried to devise a model screening test, using common parameters available in most ordinary hospitals, to predict PVH. Multiple regression analysis was performed by setting up the PVH% (the volume percentage of PVH to cranial cavity) as a dependent variable and twenty-seven variables associated with general medical examination and brain atrophy as explanatory variables. We found that arteriosclerotic changes in the body as well as brain atrophy were significantly correlated with PVH, and that PVH could be predicted with a high contribution ratio of 0.70. It is clinically important to examine the elderly with our screening test to predict PVH in order to detect the early stages of ischemia.

Original languageEnglish
Pages (from-to)183-191
Number of pages9
JournalArchives of Gerontology and Geriatrics
Issue number2
Publication statusPublished - 1992


  • Arteriosclerosis
  • Brain atrophy
  • Magnetic resonance imaging (MRI)
  • Periventricular hyperintensity (PVH)
  • Risk factors for stroke

ASJC Scopus subject areas

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology


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