A Visible-Light Promoted Amine Oxidation Catalyzed by a Cp*Ir Complex

Holly Jane Davis, Daniel Häussinger, Thomas R. Ward, Yasunori Okamoto

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Through a rapid screening of Cp*Ir complexes based on a turn-on type fluorescence readout, a [Cp*Ir(dipyrido[3,2-a : 2’,3’-c]phenazine)Cl]+ complex was found to catalyze the blue-light promoted dehydrogenation of N-heterocycles under physiological conditions. In the dehydrogenation of tetrahydroisoquinolines, the catalyst preferentially yielded the monodehydrogenated product, accompanying H2O2 generation. We surmise that this mechanism may be reminiscent of flavin-dependent oxidases.

Original languageEnglish
Pages (from-to)4512-4516
Number of pages5
JournalChemCatChem
Volume12
Issue number18
DOIs
Publication statusPublished - 2020 Sept 17

Keywords

  • Biomimetic
  • Organometallic complex
  • Photocatalysis
  • Reaction-in-water
  • Selective-dehydrogenation

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