Abasic-site-containing oligodeoxynucleotides as aptamers for riboflavin

N. B. Sankaran; Seiichi Nishizawa; Takehiro Seino; Keitaro Yoshimoto; Norio Teramae

doi:10.1002/anie.200502979

Abasic-site-containing oligodeoxynucleotides as aptamers for riboflavin

N. B. Sankaran, Seiichi Nishizawa, Takehiro Seino, Keitaro Yoshimoto, Norio Teramae

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

Abstract

Finding flavins: A new class of DNA-duplex aptamers that bind to riboflavin by utilizing an abasic (AP) site has been developed (see model). An optimized duplex shows high selectivity for riboflavin over flavin mononucleotide and flavin adenine dinucleotide. Such riboflavin-duplex interactions are discussed as a basis for the further development of AP-site-based DNA aptamers. (Figure Presented).

Original language	English
Pages (from-to)	1563-1568
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	10
DOIs	https://doi.org/10.1002/anie.200502979
Publication status	Published - 2006 Feb 27

Keywords

Abasic sites
Aptamers
Flavins
Fluorescence probes
Nucleic acids

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abstract = "Finding flavins: A new class of DNA-duplex aptamers that bind to riboflavin by utilizing an abasic (AP) site has been developed (see model). An optimized duplex shows high selectivity for riboflavin over flavin mononucleotide and flavin adenine dinucleotide. Such riboflavin-duplex interactions are discussed as a basis for the further development of AP-site-based DNA aptamers. (Figure Presented).",

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AU - Sankaran, N. B.

AU - Nishizawa, Seiichi

AU - Seino, Takehiro

AU - Yoshimoto, Keitaro

AU - Teramae, Norio

PY - 2006/2/27

Y1 - 2006/2/27

N2 - Finding flavins: A new class of DNA-duplex aptamers that bind to riboflavin by utilizing an abasic (AP) site has been developed (see model). An optimized duplex shows high selectivity for riboflavin over flavin mononucleotide and flavin adenine dinucleotide. Such riboflavin-duplex interactions are discussed as a basis for the further development of AP-site-based DNA aptamers. (Figure Presented).

AB - Finding flavins: A new class of DNA-duplex aptamers that bind to riboflavin by utilizing an abasic (AP) site has been developed (see model). An optimized duplex shows high selectivity for riboflavin over flavin mononucleotide and flavin adenine dinucleotide. Such riboflavin-duplex interactions are discussed as a basis for the further development of AP-site-based DNA aptamers. (Figure Presented).

KW - Abasic sites

KW - Aptamers

KW - Flavins

KW - Fluorescence probes

KW - Nucleic acids

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JF - Angewandte Chemie - International Edition

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Abasic-site-containing oligodeoxynucleotides as aptamers for riboflavin

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Keywords

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