Aberrant progenitors common to megakaryocytic and myeloid cells in a Down's infant with transient abnormal myelopoiesis

Atsushi Sato; Masue Imaizumi; Tomoyo Noro; Ryo Ichinohasama; Toshiaki Saito; Miyako Yoshinari; Naruyoshi Suwabe; Hoshiro Suzuki; Yoshitsugu Koizumi; Yan Cui; Masayuki Yamamoto; Kazuie Iinuma

doi:10.1016/0145-2126(95)00065-8

Aberrant progenitors common to megakaryocytic and myeloid cells in a Down's infant with transient abnormal myelopoiesis

Atsushi Sato, Masue Imaizumi, Tomoyo Noro, Ryo Ichinohasama, Toshiaki Saito, Miyako Yoshinari, Naruyoshi Suwabe, Hoshiro Suzuki, Yoshitsugu Koizumi, Yan Cui, Masayuki Yamamoto, Kazuie Iinuma

Tohoku Medical Megabank Organization (ToMMo)

Tohoku University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Phenotypic characteristics of blasts were studied in a Down's infant with transient abnormal myelopoiesis (TAM). Two major subpopulations were identified: (1) CD33+CD42b+ cells with platelet peroxidase activity, the commitment of which to megakaryocytic lineage was supported by an increased expression of GATA-1 mRNA; (2) CD33+CD34+CD7+CD4+ cells with immature ultrastructure, which could be either immature megakaryocytic or myeloid cells with aberrant differentiation. Mixed colonies containing megakaryocytes and monocyte/macrophages in the peripheral blood suggested the presence of progenitors common to these subpopulations. These results may indicate that subpopulations of blasts with phenotypic diversity could be derived from aberrant common progenitors to megakaryocytic and myeloid lineages in this patient.

Original language	English
Pages (from-to)	811-813,815
Journal	Leukemia Research
Volume	19
Issue number	11
DOIs	https://doi.org/10.1016/0145-2126(95)00065-8
Publication status	Published - 1995 Nov

Keywords

GATA-1
Transient abnormal myelopoiesis
mixed colonies
multilineage phenotypes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0145-2126(95)00065-8

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title = "Aberrant progenitors common to megakaryocytic and myeloid cells in a Down's infant with transient abnormal myelopoiesis",

abstract = "Phenotypic characteristics of blasts were studied in a Down's infant with transient abnormal myelopoiesis (TAM). Two major subpopulations were identified: (1) CD33+CD42b+ cells with platelet peroxidase activity, the commitment of which to megakaryocytic lineage was supported by an increased expression of GATA-1 mRNA; (2) CD33+CD34+CD7+CD4+ cells with immature ultrastructure, which could be either immature megakaryocytic or myeloid cells with aberrant differentiation. Mixed colonies containing megakaryocytes and monocyte/macrophages in the peripheral blood suggested the presence of progenitors common to these subpopulations. These results may indicate that subpopulations of blasts with phenotypic diversity could be derived from aberrant common progenitors to megakaryocytic and myeloid lineages in this patient.",

keywords = "GATA-1, Transient abnormal myelopoiesis, mixed colonies, multilineage phenotypes",

author = "Atsushi Sato and Masue Imaizumi and Tomoyo Noro and Ryo Ichinohasama and Toshiaki Saito and Miyako Yoshinari and Naruyoshi Suwabe and Hoshiro Suzuki and Yoshitsugu Koizumi and Yan Cui and Masayuki Yamamoto and Kazuie Iinuma",

year = "1995",

month = nov,

doi = "10.1016/0145-2126(95)00065-8",

language = "English",

volume = "19",

pages = "811--813,815",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Aberrant progenitors common to megakaryocytic and myeloid cells in a Down's infant with transient abnormal myelopoiesis

AU - Sato, Atsushi

AU - Imaizumi, Masue

AU - Noro, Tomoyo

AU - Ichinohasama, Ryo

AU - Saito, Toshiaki

AU - Yoshinari, Miyako

AU - Suwabe, Naruyoshi

AU - Suzuki, Hoshiro

AU - Koizumi, Yoshitsugu

AU - Cui, Yan

AU - Yamamoto, Masayuki

AU - Iinuma, Kazuie

PY - 1995/11

Y1 - 1995/11

N2 - Phenotypic characteristics of blasts were studied in a Down's infant with transient abnormal myelopoiesis (TAM). Two major subpopulations were identified: (1) CD33+CD42b+ cells with platelet peroxidase activity, the commitment of which to megakaryocytic lineage was supported by an increased expression of GATA-1 mRNA; (2) CD33+CD34+CD7+CD4+ cells with immature ultrastructure, which could be either immature megakaryocytic or myeloid cells with aberrant differentiation. Mixed colonies containing megakaryocytes and monocyte/macrophages in the peripheral blood suggested the presence of progenitors common to these subpopulations. These results may indicate that subpopulations of blasts with phenotypic diversity could be derived from aberrant common progenitors to megakaryocytic and myeloid lineages in this patient.

AB - Phenotypic characteristics of blasts were studied in a Down's infant with transient abnormal myelopoiesis (TAM). Two major subpopulations were identified: (1) CD33+CD42b+ cells with platelet peroxidase activity, the commitment of which to megakaryocytic lineage was supported by an increased expression of GATA-1 mRNA; (2) CD33+CD34+CD7+CD4+ cells with immature ultrastructure, which could be either immature megakaryocytic or myeloid cells with aberrant differentiation. Mixed colonies containing megakaryocytes and monocyte/macrophages in the peripheral blood suggested the presence of progenitors common to these subpopulations. These results may indicate that subpopulations of blasts with phenotypic diversity could be derived from aberrant common progenitors to megakaryocytic and myeloid lineages in this patient.

KW - GATA-1

KW - Transient abnormal myelopoiesis

KW - mixed colonies

KW - multilineage phenotypes

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U2 - 10.1016/0145-2126(95)00065-8

DO - 10.1016/0145-2126(95)00065-8

M3 - Article

C2 - 8551797

AN - SCOPUS:0029565868

SN - 0145-2126

VL - 19

SP - 811-813,815

JO - Leukemia Research

JF - Leukemia Research

IS - 11

ER -

Aberrant progenitors common to megakaryocytic and myeloid cells in a Down's infant with transient abnormal myelopoiesis

Abstract

Keywords

UN SDGs

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