Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration

Chihiro Ueyama, Hiroki Akashiba, Keiko Nakayama, Keiichi I. Nakayama, Nobuyoshi Nishiyama, Norio Matsuki

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


p27 is a cyclin-dependent kinase inhibitor which arrests cell cycle at G1-S phase. Using RNA interference method, we previously showed that reduction of endogenous p27 expression induces cell death through cell cycle progression in cultured cortical neurons. In this study, we investigated responses to kainate treatment using p27 knockout mice. Injection of kainic acid induced p27 downregulation and retinoblastoma protein phosphorylation in wild-type mouse hippocampus. No change was observed in hippocampal cell viability in untreated adult p27 heterozygous and homozygous mice compared with wild type (+/+). p27 homozygous mice, however, displayed enhanced seizure and hippocampal degeneration after kainic acid treatment. This study first suggests that ablation of p27 enhance kainate-induced seizure and hippocampal cell death in vivo.

Original languageEnglish
Pages (from-to)1781-1785
Number of pages5
Issue number17
Publication statusPublished - 2007 Nov


  • Cycle
  • Hippocampus
  • Kainic acid
  • p27
  • Seizure


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