Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E

Kazunari Sekiyama, Osamu Hashimoto, Yuuki Ushiro, Chika Adachi, Takefumi Kikusui, Kentaro Tanemura, Yoshihisa Hasegawa

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


To study the function of activin E, a TGF-β superfamily member, in the regulation of affective behavior, we investigated the behavior of transgenic mice overexpressing activin E (TgActβE mice). Male TgActβE mice showed aggressive behavior in resident-intruder tests. In elevated plus-maze tests, the percentage of open arm entries was significantly increased in female TgActβE mice compared with that in wild-type mice. Furthermore, female TgActβE mice stayed in the central area for a significantly longer time than wild-type mice in open field tests. These results indicated that TgActβE mice had less anxiety-like behavior. The number of restraint-stress-evoked c-Fos-positive cells in the hypothalamic paraventricular nucleus in TgActβE mice was significantly decreased compared with that in wild-type mice. This suggests that synthesis of corticotrophin-releasing hormone induced by stress was decreased in TgActβE mice. Taking these results together, activin E may act as a regulator of the hypothalamic-pituitary-adrenal axis.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - 2009 Jul 31


  • Activin E
  • Aggression
  • Anxiety
  • Transgenic mouse


Dive into the research topics of 'Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E'. Together they form a unique fingerprint.

Cite this