Absence of p51 mutation in human hepatocellular carcinoma

Kunihiro Hamada; Toru Koyama; Kimihiro Shimizu; Shuntaro Ikawa; Susumu Kawate; Jun Yokota; Susumu Ohwada; Yasuo Morishita

doi:10.1016/S0304-3835(99)00330-4

Absence of p51 mutation in human hepatocellular carcinoma

Kunihiro Hamada, Toru Koyama, Kimihiro Shimizu, Shuntaro Ikawa, Susumu Kawate, Jun Yokota, Susumu Ohwada, Yasuo Morishita

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The p51 gene encodes a protein with significant homology to p53. To investigate the involvement of the p51 gene in human hepatocarcinogenesis, mutation analysis of the p51 gene was performed in 54 cases of hepatocellular carcinoma (HCC). No mutations causing amino acid substitutions or frameshifts were found by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis of the entire coding region. The result indicated that mutation of the p51 gene does not play a major role in the development of HCC in Japanese patients. Further studies on p51 expression and its functions, including the interaction with p53, are necessary to elucidate the role of the p51 gene in human hepatocarcinogenesis.

Original language	English
Pages (from-to)	161-164
Number of pages	4
Journal	Cancer Letters
Volume	148
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(99)00330-4
Publication status	Published - 2000 Feb 1
Externally published	Yes

Keywords

Hepatocellular carcinoma
Mutation
p51 gene
p53 family

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(99)00330-4

Cite this

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title = "Absence of p51 mutation in human hepatocellular carcinoma",

abstract = "The p51 gene encodes a protein with significant homology to p53. To investigate the involvement of the p51 gene in human hepatocarcinogenesis, mutation analysis of the p51 gene was performed in 54 cases of hepatocellular carcinoma (HCC). No mutations causing amino acid substitutions or frameshifts were found by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis of the entire coding region. The result indicated that mutation of the p51 gene does not play a major role in the development of HCC in Japanese patients. Further studies on p51 expression and its functions, including the interaction with p53, are necessary to elucidate the role of the p51 gene in human hepatocarcinogenesis.",

keywords = "Hepatocellular carcinoma, Mutation, p51 gene, p53 family",

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doi = "10.1016/S0304-3835(99)00330-4",

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T1 - Absence of p51 mutation in human hepatocellular carcinoma

AU - Hamada, Kunihiro

AU - Koyama, Toru

AU - Shimizu, Kimihiro

AU - Ikawa, Shuntaro

AU - Kawate, Susumu

AU - Yokota, Jun

AU - Ohwada, Susumu

AU - Morishita, Yasuo

PY - 2000/2/1

Y1 - 2000/2/1

N2 - The p51 gene encodes a protein with significant homology to p53. To investigate the involvement of the p51 gene in human hepatocarcinogenesis, mutation analysis of the p51 gene was performed in 54 cases of hepatocellular carcinoma (HCC). No mutations causing amino acid substitutions or frameshifts were found by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis of the entire coding region. The result indicated that mutation of the p51 gene does not play a major role in the development of HCC in Japanese patients. Further studies on p51 expression and its functions, including the interaction with p53, are necessary to elucidate the role of the p51 gene in human hepatocarcinogenesis.

AB - The p51 gene encodes a protein with significant homology to p53. To investigate the involvement of the p51 gene in human hepatocarcinogenesis, mutation analysis of the p51 gene was performed in 54 cases of hepatocellular carcinoma (HCC). No mutations causing amino acid substitutions or frameshifts were found by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis of the entire coding region. The result indicated that mutation of the p51 gene does not play a major role in the development of HCC in Japanese patients. Further studies on p51 expression and its functions, including the interaction with p53, are necessary to elucidate the role of the p51 gene in human hepatocarcinogenesis.

KW - Hepatocellular carcinoma

KW - Mutation

KW - p51 gene

KW - p53 family

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DO - 10.1016/S0304-3835(99)00330-4

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JO - Cancer Letters

JF - Cancer Letters

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ER -

Absence of p51 mutation in human hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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