Accelerating effects of cellulase in the removal of denture adhesives from acrylic denture bases

Kae Harada-Hada, Sumiyo Mimura, Guang Hong, Tatsumi Hashida, Hitoshi Abekura, Hiroshi Murata, Masahiro Nishimura, Hiroki Nikawa

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Purpose Studies of effective methods for the easy removal of denture adhesives from a denture base are not well represented in the literature. We previously assessed the removability of denture adhesives by immersing within denture cleaners, showing that some cleaners have a weak effect, insufficiently effective in daily use. In this study, we prepared a cellulase, as a potential component for denture adhesive removers, and we examined whether the addition of cellulase to denture cleaners is effective in the removal of cream denture adhesives. Methods We prepared the cellulase Meicelase as one component for the liquefaction of denture adhesives. We used two denture cleaners and two cream adhesives. After the immersion of plates in sample solutions, we evaluated the area of the sample plate still covered with adhesives. Biofilm removal assay was also performed using denture cleaners containing cellulase. Results The addition of cellulase accelerated the removal of cream adhesives in immersion experiments to a rate faster than that of water and denture cleaners. However, it did not influence the removability of Candida albicans biofilms from acrylic resin specimens. Conclusion Cellulase hastened the liquefaction of cream adhesives.

Original languageEnglish
Pages (from-to)185-192
Number of pages8
JournalJournal of Prosthodontic Research
Issue number2
Publication statusPublished - 2017 Apr


  • Candida albicans biofilm
  • Cellulase
  • Denture adhesive
  • Denture cleaner
  • Meicelase

ASJC Scopus subject areas

  • Oral Surgery
  • Dentistry (miscellaneous)


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