TY - JOUR
T1 - Acrokeratosis paraneoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata
AU - Hara, M.
AU - Hunayama, M.
AU - Aiba, S.
AU - Suetake, T.
AU - Watanabe, M.
AU - Tanaka, M.
AU - Tagami, H.
PY - 1995
Y1 - 1995
N2 - We report a case of acrokeratosis paraneoplastica (AP; Bazex syndrome), characterized by typical palmoplantar hyperkeratosis and psoriasiform scaly erythema of the acral regions, associated with primary cutaneous squamous cell carcinoma (SCC) on the left lower leg. This 54-year-old Japanese man subsequently developed vitiligo, and alopecia areata of the scalp. Serial monitoring of squamous cell carcinoma antigen (SCC-Ag) demonstrated that the severity of the clinical manifestations of AP paralleled the serum concentrations of SCC-Ag. We suggest that an immune-mediated mechanism underlies the development of AP in this patient.
AB - We report a case of acrokeratosis paraneoplastica (AP; Bazex syndrome), characterized by typical palmoplantar hyperkeratosis and psoriasiform scaly erythema of the acral regions, associated with primary cutaneous squamous cell carcinoma (SCC) on the left lower leg. This 54-year-old Japanese man subsequently developed vitiligo, and alopecia areata of the scalp. Serial monitoring of squamous cell carcinoma antigen (SCC-Ag) demonstrated that the severity of the clinical manifestations of AP paralleled the serum concentrations of SCC-Ag. We suggest that an immune-mediated mechanism underlies the development of AP in this patient.
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U2 - 10.1111/j.1365-2133.1995.tb02504.x
DO - 10.1111/j.1365-2133.1995.tb02504.x
M3 - Article
C2 - 7669622
AN - SCOPUS:0029058325
SN - 0007-0963
VL - 133
SP - 121
EP - 124
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 1
ER -