Activation of ATP receptor increases the cytosolic Ca2+ concentration in ventral tegmental area neurons of rat brain

Masaru Sorimachi, Kazuhiko Yamagami, Minoru Wakomori

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

ATP increased the cytosolic Ca2+ concentration ([Ca]i) in neurons of ventral tegmental area acutely dissociated from rat brain. The ATP response was dependent on external Ca2+ and Na+, and was blocked by voltage-dependent Ca2+ channel blockers. The results suggest that the ATP-induced depolarization increases Ca2+ influx via voltage-gated Ca2+ channels resulting in the increase in [Ca]i.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalBrain Research
Volume935
Issue number1-2
DOIs
Publication statusPublished - 2002 May 10

Keywords

  • ATP
  • Ca channel
  • Fura-2 microfluorometry
  • Purinoceptor
  • Ventral tegmental area

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