TY - JOUR
T1 - Activation of extracellular signal-regulated kinase in MDBK cells infected with bovine viral diarrhea virus.
AU - Yamane, Daisuke
AU - Zahoor, Muhammad Atif
AU - Mohamed, Yassir Mahgoub
AU - Azab, Walid
AU - Kato, Kentaro
AU - Tohya, Yukinobu
AU - Akashi, Hiroomi
N1 - Funding Information:
This work was supported in part by the Grant-in-Aid from the Ministry of Agriculture, Forestry, and Fisheries of Japan, from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and from the Japan Society for the Promotion of Science.
PY - 2009
Y1 - 2009
N2 - Our efforts to identify the cellular signaling cascades triggered by bovine viral diarrhea virus (BVDV) infection in MDBK cells revealed marked activation of extracellular signal-regulated kinase 1/2 (ERK). Enhanced phosphorylation of ERK was detected following infection with cytopathogenic (cp) BVDV, but not with noncytopathogenic BVDV. It appears that cp BVDV-induced ERK phosphorylation is caused by oxidative stress, because ERK phosphorylation was inducible by treatment with hydrogen peroxide or serum deprivation and was attenuated by addition of antioxidants. These results indicate that BVDV infection influences the ERK signaling pathway via oxidative stress, depending on the biotype.
AB - Our efforts to identify the cellular signaling cascades triggered by bovine viral diarrhea virus (BVDV) infection in MDBK cells revealed marked activation of extracellular signal-regulated kinase 1/2 (ERK). Enhanced phosphorylation of ERK was detected following infection with cytopathogenic (cp) BVDV, but not with noncytopathogenic BVDV. It appears that cp BVDV-induced ERK phosphorylation is caused by oxidative stress, because ERK phosphorylation was inducible by treatment with hydrogen peroxide or serum deprivation and was attenuated by addition of antioxidants. These results indicate that BVDV infection influences the ERK signaling pathway via oxidative stress, depending on the biotype.
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U2 - 10.1007/s00705-009-0453-2
DO - 10.1007/s00705-009-0453-2
M3 - Article
C2 - 19609634
AN - SCOPUS:70449699812
SN - 0304-8608
VL - 154
SP - 1499
EP - 1503
JO - Archives of Virology
JF - Archives of Virology
IS - 9
ER -
