Acute gastric outlet obstruction following the administration of prostaglandin: An additional case

Nobuo Kobayashi; Noriko Aida; Gen Nishimura; Tohko Kashimura; Mayumi Ohta; Motoyoshi Kawataki

doi:10.1007/s002470050064

Acute gastric outlet obstruction following the administration of prostaglandin: An additional case

Nobuo Kobayashi, Noriko Aida, Gen Nishimura, Tohko Kashimura, Mayumi Ohta, Motoyoshi Kawataki

Obstetrics, Gynecology and Urology

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We present a case of neonatal acute gastric outlet obstruction related to prostaglandin-induced gastric foveolar hyperplasia, which developed following infusion of prostaglandin E₁ (PGE₁) for treatment of hypoplastic left heart syndrome. Abdominal distension occurred after administration of PGE₁ in a cumulative dose of 2914 μg/kg. Ultrasonography performed after a cumulative dose of 5074 μg/kg had been administered disclosed a lobulated thickening of the gastric mucosa with a brush-like appearance composed of alternately echogenic and hypoechoic, vertically oriented lines. These ultrasonographic findings corresponded to the histological abnormalities of gastric foveolar hyperplasia with impacted interfoveolar mucin products and dilated mucosal glands. The development of gastric outlet obstruction in our patient, a relatively rare manifestation of prostaglandin-induced foveolar hyperplasia, might have been related to the unusually high cumulative dose of PGE₁.

Original language	English
Pages (from-to)	57-59
Number of pages	3
Journal	Pediatric Radiology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1007/s002470050064
Publication status	Published - 1997 Jan

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Radiology Nuclear Medicine and imaging

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abstract = "We present a case of neonatal acute gastric outlet obstruction related to prostaglandin-induced gastric foveolar hyperplasia, which developed following infusion of prostaglandin E1 (PGE1) for treatment of hypoplastic left heart syndrome. Abdominal distension occurred after administration of PGE1 in a cumulative dose of 2914 μg/kg. Ultrasonography performed after a cumulative dose of 5074 μg/kg had been administered disclosed a lobulated thickening of the gastric mucosa with a brush-like appearance composed of alternately echogenic and hypoechoic, vertically oriented lines. These ultrasonographic findings corresponded to the histological abnormalities of gastric foveolar hyperplasia with impacted interfoveolar mucin products and dilated mucosal glands. The development of gastric outlet obstruction in our patient, a relatively rare manifestation of prostaglandin-induced foveolar hyperplasia, might have been related to the unusually high cumulative dose of PGE1.",

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AU - Kobayashi, Nobuo

AU - Aida, Noriko

AU - Nishimura, Gen

AU - Kashimura, Tohko

AU - Ohta, Mayumi

AU - Kawataki, Motoyoshi

PY - 1997/1

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N2 - We present a case of neonatal acute gastric outlet obstruction related to prostaglandin-induced gastric foveolar hyperplasia, which developed following infusion of prostaglandin E1 (PGE1) for treatment of hypoplastic left heart syndrome. Abdominal distension occurred after administration of PGE1 in a cumulative dose of 2914 μg/kg. Ultrasonography performed after a cumulative dose of 5074 μg/kg had been administered disclosed a lobulated thickening of the gastric mucosa with a brush-like appearance composed of alternately echogenic and hypoechoic, vertically oriented lines. These ultrasonographic findings corresponded to the histological abnormalities of gastric foveolar hyperplasia with impacted interfoveolar mucin products and dilated mucosal glands. The development of gastric outlet obstruction in our patient, a relatively rare manifestation of prostaglandin-induced foveolar hyperplasia, might have been related to the unusually high cumulative dose of PGE1.

AB - We present a case of neonatal acute gastric outlet obstruction related to prostaglandin-induced gastric foveolar hyperplasia, which developed following infusion of prostaglandin E1 (PGE1) for treatment of hypoplastic left heart syndrome. Abdominal distension occurred after administration of PGE1 in a cumulative dose of 2914 μg/kg. Ultrasonography performed after a cumulative dose of 5074 μg/kg had been administered disclosed a lobulated thickening of the gastric mucosa with a brush-like appearance composed of alternately echogenic and hypoechoic, vertically oriented lines. These ultrasonographic findings corresponded to the histological abnormalities of gastric foveolar hyperplasia with impacted interfoveolar mucin products and dilated mucosal glands. The development of gastric outlet obstruction in our patient, a relatively rare manifestation of prostaglandin-induced foveolar hyperplasia, might have been related to the unusually high cumulative dose of PGE1.

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Acute gastric outlet obstruction following the administration of prostaglandin: An additional case

Abstract

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