Acute-onset autoimmune hepatitis in a patient with selective immunoglobulin M deficiency

Akitoshi Sano, Jun Inoue, Eiji Kakazu, Masashi Ninomiya, Tomoaki Iwata, Tatsuki Morosawa, Satoshi Takai, Takuya Nakamura, Atsushi Masamune

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Selective immunoglobulin M deficiency (SIGMD) is an uncommon primary immunodeficiency disorder. We herein report an SIGMD patient with autoimmune hepatitis. A 21-year-old Japanese man was transferred to our hospital because of acute liver dysfunction. His serum IgM level was low, whereas those of IgG and IgA were normal, indicating that he had SIGMD. We diagnosed him with acute-onset autoimmune hepatitis, and his liver function test findings gradually recovered with corticosteroid administration. Although SIGMD with autoimmune diseases has been reported, the clinical features and pathogenesis have not yet been clarified. We have summarized previous reports on SIGMD patients with autoimmune diseases.

Original languageEnglish
Pages (from-to)2185-2190
Number of pages6
JournalInternal Medicine
Issue number15
Publication statusPublished - 2019


  • Autoimmune hepatitis
  • Selective immunoglobulin M deficiency

ASJC Scopus subject areas

  • Internal Medicine


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