Adaptation to hydrogen peroxide enhances PC12 cell tolerance against oxidative damage

Zhi Hua Chen, Yasukazu Yoshida, Yoshiro Saito, Etsuo Niki

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


The adaptive responses to H2O2 and the resulting protective effect against oxidative stress have been investigated using PC12 cells. Pretreatment of sublethal doses of H2O2 significantly protected PC12 cells against the cytotoxicity induced by lethal H2O2. The endogenous antioxidant defense systems, catalase and glutathione peroxidase, were enhanced quickly by the pretreatment of low doses of H2O2. This pretreatment also exerted protective effect against the oxidative insults induced by 6-hydroxydopamine and paraquat, but not against alkyl peroxyl radicals. Our results, taken together, suggest that the stimulation by low dose of H2O2 enriches the cellular antioxidant defense systems, thereby enhancing cell tolerance against the forthcoming oxidative insults induced by H2O2 and related hydroxyl radicals.

Original languageEnglish
Pages (from-to)256-259
Number of pages4
JournalNeuroscience Letters
Issue number3
Publication statusPublished - 2005 Aug 5


  • Adaptation
  • Catalase
  • Glutathione peroxidase
  • Hydrogen peroxide


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