Adaptive response induced by lipid peroxidation products in cell cultures

Zhi Hua Chen; Yasukazu Yoshida; Yoshiro Saito; Noriko Noguchi; Etsuo Niki

doi:10.1016/j.febslet.2005.12.045

Adaptive response induced by lipid peroxidation products in cell cultures

Zhi Hua Chen, Yasukazu Yoshida, Yoshiro Saito, Noriko Noguchi, Etsuo Niki

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The adaptive response induced by the lipid peroxidation products, such as phosphatidylcholine hydroperoxide, lysophosphatidylcholine (LysoPC), 15-deoxy-Δ^12,14-prostaglandin J₂, 4-hydroxynonenal (4-HNE), hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and cholesterol 5β,6β-epoxide, was investigated in this study. Although these products have been implicated in oxidative stress-related diseases, pretreatment with such compounds at sublethal concentrations significantly protected PC12 cells against subsequent oxidative stress induced by 6-hydroxydopamine. Moreover, 4-HNE and LysoPC also exhibited adaptive protection in human arterial endothelial cells. These findings suggest a general hormetic effect of such compounds in cell cultures and may lead to a reappraisal of the eventual role of reactive oxygen species and lipid peroxidation in organisms.

Original language	English
Pages (from-to)	479-483
Number of pages	5
Journal	FEBS Letters
Volume	580
Issue number	2
DOIs	https://doi.org/10.1016/j.febslet.2005.12.045
Publication status	Published - 2006 Jan 23
Externally published	Yes

Keywords

Adaptive response
Cytotoxicity
Lipid peroxidation products
Oxidative stress

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2005.12.045

Cite this

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title = "Adaptive response induced by lipid peroxidation products in cell cultures",

abstract = "The adaptive response induced by the lipid peroxidation products, such as phosphatidylcholine hydroperoxide, lysophosphatidylcholine (LysoPC), 15-deoxy-Δ12,14-prostaglandin J2, 4-hydroxynonenal (4-HNE), hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and cholesterol 5β,6β-epoxide, was investigated in this study. Although these products have been implicated in oxidative stress-related diseases, pretreatment with such compounds at sublethal concentrations significantly protected PC12 cells against subsequent oxidative stress induced by 6-hydroxydopamine. Moreover, 4-HNE and LysoPC also exhibited adaptive protection in human arterial endothelial cells. These findings suggest a general hormetic effect of such compounds in cell cultures and may lead to a reappraisal of the eventual role of reactive oxygen species and lipid peroxidation in organisms.",

keywords = "Adaptive response, Cytotoxicity, Lipid peroxidation products, Oxidative stress",

author = "Chen, {Zhi Hua} and Yasukazu Yoshida and Yoshiro Saito and Noriko Noguchi and Etsuo Niki",

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doi = "10.1016/j.febslet.2005.12.045",

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T1 - Adaptive response induced by lipid peroxidation products in cell cultures

AU - Chen, Zhi Hua

AU - Yoshida, Yasukazu

AU - Saito, Yoshiro

AU - Noguchi, Noriko

AU - Niki, Etsuo

PY - 2006/1/23

Y1 - 2006/1/23

N2 - The adaptive response induced by the lipid peroxidation products, such as phosphatidylcholine hydroperoxide, lysophosphatidylcholine (LysoPC), 15-deoxy-Δ12,14-prostaglandin J2, 4-hydroxynonenal (4-HNE), hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and cholesterol 5β,6β-epoxide, was investigated in this study. Although these products have been implicated in oxidative stress-related diseases, pretreatment with such compounds at sublethal concentrations significantly protected PC12 cells against subsequent oxidative stress induced by 6-hydroxydopamine. Moreover, 4-HNE and LysoPC also exhibited adaptive protection in human arterial endothelial cells. These findings suggest a general hormetic effect of such compounds in cell cultures and may lead to a reappraisal of the eventual role of reactive oxygen species and lipid peroxidation in organisms.

AB - The adaptive response induced by the lipid peroxidation products, such as phosphatidylcholine hydroperoxide, lysophosphatidylcholine (LysoPC), 15-deoxy-Δ12,14-prostaglandin J2, 4-hydroxynonenal (4-HNE), hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and cholesterol 5β,6β-epoxide, was investigated in this study. Although these products have been implicated in oxidative stress-related diseases, pretreatment with such compounds at sublethal concentrations significantly protected PC12 cells against subsequent oxidative stress induced by 6-hydroxydopamine. Moreover, 4-HNE and LysoPC also exhibited adaptive protection in human arterial endothelial cells. These findings suggest a general hormetic effect of such compounds in cell cultures and may lead to a reappraisal of the eventual role of reactive oxygen species and lipid peroxidation in organisms.

KW - Adaptive response

KW - Cytotoxicity

KW - Lipid peroxidation products

KW - Oxidative stress

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JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Adaptive response induced by lipid peroxidation products in cell cultures

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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