@article{86c703020eb649fabb15fb3ed612c573,
title = "Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing",
abstract = "White adipocytes activate the lipolysis pathway to produce the free fatty acids that are used as heating fuel by brown adipose tissue. Nayak et al. show that Opsin 3 is required for blue-light-enhanced activation of the lipolysis pathway. This explains the low body temperature of Opn3 mutant mice.",
keywords = "OPN3, adipocyte, encephalopsin, light, lipolysis, metabolism, mitochondria, opsin, thermogenesis",
author = "Gowri Nayak and Zhang, {Kevin X.} and Shruti Vemaraju and Yoshinobu Odaka and Buhr, {Ethan D.} and Amanda Holt-Jones and Stace Kernodle and Smith, {April N.} and Upton, {Brian A.} and Shane D'Souza and Zhan, {Jesse J.} and Nicol{\'a}s Diaz and Nguyen, {Minh Thanh} and Rajib Mukherjee and Gordon, {Shannon A.} and Gang Wu and Robert Schmidt and Xue Mei and Petts, {Nathan T.} and Matthew Batie and Sujata Rao and Hogenesch, {John B.} and Takahisa Nakamura and Alison Sweeney and Seeley, {Randy J.} and {Van Gelder}, {Russell N.} and Joan Sanchez-Gurmaches and Lang, {Richard A.}",
note = "Funding Information: We thank Paul Speeg for excellent mouse colony management and the Transgenic Animal and Genome Editing Core at Cincinnati Children{\textquoteright}s Hospital. We thank Kwoon Y. Wong at the University of Michigan, Ann Arbor, for providing the Opn4 cre ; Z/EG mouse line. This work was supported by NIH R01 GM124246 (to E.D.B.), R01EY026921 (to R.N.V.G.), P30EY001730 (to the University of Washington), R01 DK107530 (to T.N.), R01 EY027077 (to R.A.L. and S.R.), R01 EY027711 (to P. Michael Iuvone, Emory University , and R.A.L.); NIGMS T32 GM063483 (to the University of Cincinnati Medical Scientist Training Program); NIH P30 DK089503 (to R.J.S. and the Michigan Nutrition Obesity Research Center); the Mark J. Daily, MD Research Fund (to the University of Washington); and unrestricted grants to the University of Washington and Emory University Departments of Ophthalmology from Research to Prevent Blindness . This work was also supported by a Packard Foundation fellowship (to A.S.); American Heart Association grant 18CDA34080527 (to J.S.-G.); American Heart Association postdoctoral fellowship 19POST34380545 (to R.M.); and funds from the Goldman Chair of the Abrahamson Pediatric Eye Institute at Cincinnati Children{\textquoteright}s Hospital Medical Center. Funding Information: We thank Paul Speeg for excellent mouse colony management and the Transgenic Animal and Genome Editing Core at Cincinnati Children's Hospital. We thank Kwoon Y. Wong at the University of Michigan, Ann Arbor, for providing the Opn4cre; Z/EG mouse line. This work was supported by NIH R01 GM124246 (to E.D.B.), R01EY026921 (to R.N.V.G.), P30EY001730 (to the University of Washington), R01 DK107530 (to T.N.), R01 EY027077 (to R.A.L. and S.R.), R01 EY027711 (to P. Michael Iuvone, Emory University, and R.A.L.); NIGMS T32 GM063483 (to the University of Cincinnati Medical Scientist Training Program); NIH P30 DK089503 (to R.J.S. and the Michigan Nutrition Obesity Research Center); the Mark J. Daily, MD Research Fund (to the University of Washington); and unrestricted grants to the University of Washington and Emory University Departments of Ophthalmology from Research to Prevent Blindness. This work was also supported by a Packard Foundation fellowship (to A.S.); American Heart Association grant 18CDA34080527 (to J.S.-G.); American Heart Association postdoctoral fellowship 19POST34380545 (to R.M.); and funds from the Goldman Chair of the Abrahamson Pediatric Eye Institute at Cincinnati Children's Hospital Medical Center. G.N. K.X.Z. and S.V. experimental design and analysis and manuscript preparation. Y.O. E.D.B. A.H.-J. S.K. A.N.S. B.A.U. S.D. J.J.Z. N.D. M.-T.N. R.M. S.A.G. G.W. R.S. X.M. and S.R. experimental execution and analysis. N.T.P. and M.B. electronic device design and construction. J.B.H. supervision of bioinformatics analysis. R.J.S. T.N. A.S. R.N.V.G. J.S.-G. and R.A.L. project leadership, experimental design, and manuscript preparation. R.J.S. receives research support from Novo Nordisk, Zafgen, Kallyope, Pfizer, and Ironwood Pharmaceuticals. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2020",
month = jan,
day = "21",
doi = "10.1016/j.celrep.2019.12.043",
language = "English",
volume = "30",
pages = "672--686.e8",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",
}