Addition of rhythm to non-pulsatile circulation

Tomoyuki Yambe, Kazumitsu Sekine, Yasuyuki Shiraishi, Makoto Watanabe, Mune Ichi Shibata, Tasuku Yamaguchi, Wang Quintian, Xudong Duan, Hong Jian Liu, Makoto Yoshizawa, Akira Tanaka, Hidetoshi Matsuki, Fumihiro Sato, You Ichi Haga, Masayoshi Esashi, Kouichi Tabayashi, Yoshinori Mitamura, Hiroshi Sasada, Eimei Sato, Yoshifumi SaijoShin Ichi Nitta

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


The development of a rotary blood pump (RP) is desirable as it can be used as a small ventricular assistance device (VAD). However, a RP does not generate any pulse. It may be physiologically better for the patient if the RP could generate a pulse. We have attempted to develop a device that produces a pulse in the RP. Intra-aortic balloon pumping (IABP) is effective in producing a pulse. However, the IABP cannot be implanted inside the body. Therefore, an attempt was made to develop pulse-generating equipment that was not driven by air pressure. The ball screw motor was considered as a possible candidate. In the future, we plan to apply small shape memory alloys. An electrohydraulic system was adopted, and actuator power output was connected to the diaphragm. The diaphragm was placed outside the ventricle. Most RPs developed throughout the world drain blood from the ventricle. The pulse wave should be generated if a pulse is added by the part from which blood is being drawn. In this study, animal experiments were conducted and the output assistance was tested from outside the ventricle. The device operated effectively in the animal experiment. The RP can easily be equipped with this device at the time of performing the implant operation. For a patient with problems of peripheral circulation and the internal organ fiunction, it may prove to be an effective device.

Original languageEnglish
Pages (from-to)S145-S149
JournalBiomedicine and Pharmacotherapy
Issue numberSUPPL. 1
Publication statusPublished - 2004 Oct


  • Artificial myocardium
  • Ball screw
  • Electrohydraulic system
  • Pulsation device
  • Rotary blood pump


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