TY - JOUR
T1 - Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice
AU - Hou, Yongyong
AU - Liu, Zhiyuan
AU - Zuo, Zhuo
AU - Gao, Tianchang
AU - Fu, Jingqi
AU - Wang, Huihui
AU - Xu, Yuanyuan
AU - Liu, Dianxin
AU - Yamamoto, Masayuki
AU - Zhu, Beibei
AU - Zhang, Yiguo
AU - Andersen, Melvin E.
AU - Zhang, Qiang
AU - Pi, Jingbo
N1 - Funding Information:
This research was supported by National Natural Science Foundation of China (grant numbers: 81573106 and 81402661 ), the Startup Funding of China Medical University (Jingbo Pi) and Liaoning Pandeng Scholar (Jingbo Pi).
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/9/3
Y1 - 2018/9/3
N2 - The maintenance of healthy adipose tissues is essential for efficient regulation of energy homeostasis. Nuclear factor-erythroid 2-related factor 1 (NFE2L1, also known as Nrf1), a CNC-bZIP protein, is a master regulator of the cellular adaptive response to stresses. To investigate the role of NFE2L1 in adipocytes, we bred a line of mice with adipocyte-specific Nfe2l1 knockout (Nfe2l1(f)-KO), and found that Nfe2l1(f)-KO mice exhibited a dramatically reduced subcutaneous adipose tissue (SAT) mass, insulin resistance, adipocyte hypertrophy, and severe adipose inflammation. Mechanistic studies revealed that Nfe2l1 deficiency may disturb the expression of lipolytic genes in adipocytes, leading to adipocyte hypertrophy followed by inflammation, pyroptosis, and insulin resistance. Our findings reveal a novel role for NFE2L1 in regulating adipose tissue plasticity and energy homeostasis.
AB - The maintenance of healthy adipose tissues is essential for efficient regulation of energy homeostasis. Nuclear factor-erythroid 2-related factor 1 (NFE2L1, also known as Nrf1), a CNC-bZIP protein, is a master regulator of the cellular adaptive response to stresses. To investigate the role of NFE2L1 in adipocytes, we bred a line of mice with adipocyte-specific Nfe2l1 knockout (Nfe2l1(f)-KO), and found that Nfe2l1(f)-KO mice exhibited a dramatically reduced subcutaneous adipose tissue (SAT) mass, insulin resistance, adipocyte hypertrophy, and severe adipose inflammation. Mechanistic studies revealed that Nfe2l1 deficiency may disturb the expression of lipolytic genes in adipocytes, leading to adipocyte hypertrophy followed by inflammation, pyroptosis, and insulin resistance. Our findings reveal a novel role for NFE2L1 in regulating adipose tissue plasticity and energy homeostasis.
KW - Adipose
KW - Inflammation
KW - Lipolysis
KW - NFE2L1
KW - Pyroptosis
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U2 - 10.1016/j.bbrc.2018.06.013
DO - 10.1016/j.bbrc.2018.06.013
M3 - Article
C2 - 29935181
AN - SCOPUS:85048937579
SN - 0006-291X
VL - 503
SP - 264
EP - 270
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -