Adrenocortical peptides: Autocrine or paracrine regulators for the steroid hormone secretion or the cell proliferation?

Kazuhiro Takahashi, K. Totsune, O. Murakami

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


There is accumulating evidence that indicates the production and secretion of some peptides by adrenal cortex and adreno-cortical tumors. These peptides include adrenomedullin, pro-adrenomedullin N-terminal 20 peptide (PAMP), endothelin-1, cerebellin, urotensin-II etc., and appear to be involved in the regulation of steroid hormone secretion and the proliferation of adrenocortical cells as autocrine and/or paracrine factors. It is noteworthy that expression of adrenomedullin is induced by hypoxia and inflammatory cytokines in various cells, raising the possibility that the adrenocortical production of adrenomedullin (and probably PAMP) may be increased in some inflammatory and/or ischemic conditions, and these two peptides may modulate the states of inflammatory and/or ischemic disorders. In addition to adrenomedullin and PAMP, adrenal cortex and/or some adrenocortical tumors express endothelin-1, cerebellin, urotensin-II, etc. The adrenocortical peptides may form a novel autocrine or paracrine regulatory system for the steroid hormone secretion and the cell proliferation in the adrenal cortex, and involve in the pathophysiology of inflammatory, ischemic or neoplastic diseases of the adrenal cortex.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalExperimental and Clinical Endocrinology and Diabetes
Issue number8
Publication statusPublished - 2002 Nov


  • Adrenal
  • Adrenomedullin
  • Cerebellin
  • Endothelin
  • Urotensin

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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