TY - JOUR
T1 - Adrenocorticotropic Hormone-Independent Bilateral Adrenocortical Macronodular Hyperplasia
T2 - A Case Report and Immunohistochemical Studies
AU - Koizumi, Shigeki
AU - Beniko, Matsuo
AU - Ikota, Akemi
AU - Mizumoto, Hiroaki
AU - Matsuya, Kumiko
AU - Matsuda, Akira
AU - Sakuma, Satoshi
AU - Mashio, Yasuo
AU - Kunit, Haruhiko
AU - Okamoto, Kenzo
AU - Sasano, Hironobu
PY - 1994
Y1 - 1994
N2 - A 55-year-old woman developed Cushing's syndrome due to ACTH-independent bilateral adrenocortical macronodular hyperplasia. Plasma ACTH was undetectable, and was not stimulated by administration of metyrapone, CRH, or insulin. Hypercortisolism was not suppressed by a high dose of dexamethasone, but was responsive to ACTH. Both adrenal glands were enlarged with a total weight of 200 g, and contained multiple nodules composed of two cell types (large clear cells and small compact cells). In immunohistochemical studies, P450cl7 immunoreactivity was predominantly observed in small compact cortical cells, while that of 3βHSD was observed exclusively in large clear cortical cells. This pattern of expression of steroidogenic enzymes as well as histological and clinical features is considered to be unique to ACTH-independent bilateral adrenocortical macronodular hyperplasia.
AB - A 55-year-old woman developed Cushing's syndrome due to ACTH-independent bilateral adrenocortical macronodular hyperplasia. Plasma ACTH was undetectable, and was not stimulated by administration of metyrapone, CRH, or insulin. Hypercortisolism was not suppressed by a high dose of dexamethasone, but was responsive to ACTH. Both adrenal glands were enlarged with a total weight of 200 g, and contained multiple nodules composed of two cell types (large clear cells and small compact cells). In immunohistochemical studies, P450cl7 immunoreactivity was predominantly observed in small compact cortical cells, while that of 3βHSD was observed exclusively in large clear cortical cells. This pattern of expression of steroidogenic enzymes as well as histological and clinical features is considered to be unique to ACTH-independent bilateral adrenocortical macronodular hyperplasia.
KW - ACTH-independent bilateral adrenocortical macronodular hyperplasia
KW - Cushing's syndrome
KW - Steroidogenic enzymes
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U2 - 10.1507/endocrj.41.429
DO - 10.1507/endocrj.41.429
M3 - Article
C2 - 8528359
AN - SCOPUS:0028030981
SN - 0918-8959
VL - 41
SP - 429
EP - 435
JO - Endocrine Journal
JF - Endocrine Journal
IS - 4
ER -
