Adult-onset acquired partial lipodystrophy accompanied by rheumatoid arthritis

Yusuke Muto; Taku Fujimura; Aya Kakizaki; Kenichiro Tsuchiyama; Yoshiyuki Kusakari; Setsuya Aiba

doi:10.1159/000381844

Adult-onset acquired partial lipodystrophy accompanied by rheumatoid arthritis

Yusuke Muto, Taku Fujimura, Aya Kakizaki, Kenichiro Tsuchiyama, Yoshiyuki Kusakari, Setsuya Aiba

MED - Medical Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Lipodystrophy is a group of metabolic disorders, possibly caused by autoimmune disease. In this report, we describe a case of adult-onset acquired partial lipodystrophy accompanied by rheumatoid arthritis without a family history. Interestingly, immunohistochemical staining revealed dense infiltration of IL-27-producing cells as well as MMP-7- and MMP-28-expressing cells, both of which have been reported to facilitate the development of autoimmune disease. Our present case might suggest possible mechanisms for acquired partial lipodystrophy.

Original language	English
Pages (from-to)	70-74
Number of pages	5
Journal	Case Reports in Dermatology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1159/000381844
Publication status	Published - 2015 May 22

Keywords

Acquired partial lipodystrophy
IL-27
MMP-28
MMP-7

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10.1159/000381844

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abstract = "Lipodystrophy is a group of metabolic disorders, possibly caused by autoimmune disease. In this report, we describe a case of adult-onset acquired partial lipodystrophy accompanied by rheumatoid arthritis without a family history. Interestingly, immunohistochemical staining revealed dense infiltration of IL-27-producing cells as well as MMP-7- and MMP-28-expressing cells, both of which have been reported to facilitate the development of autoimmune disease. Our present case might suggest possible mechanisms for acquired partial lipodystrophy.",

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AU - Muto, Yusuke

AU - Fujimura, Taku

AU - Kakizaki, Aya

AU - Tsuchiyama, Kenichiro

AU - Kusakari, Yoshiyuki

AU - Aiba, Setsuya

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Lipodystrophy is a group of metabolic disorders, possibly caused by autoimmune disease. In this report, we describe a case of adult-onset acquired partial lipodystrophy accompanied by rheumatoid arthritis without a family history. Interestingly, immunohistochemical staining revealed dense infiltration of IL-27-producing cells as well as MMP-7- and MMP-28-expressing cells, both of which have been reported to facilitate the development of autoimmune disease. Our present case might suggest possible mechanisms for acquired partial lipodystrophy.

AB - Lipodystrophy is a group of metabolic disorders, possibly caused by autoimmune disease. In this report, we describe a case of adult-onset acquired partial lipodystrophy accompanied by rheumatoid arthritis without a family history. Interestingly, immunohistochemical staining revealed dense infiltration of IL-27-producing cells as well as MMP-7- and MMP-28-expressing cells, both of which have been reported to facilitate the development of autoimmune disease. Our present case might suggest possible mechanisms for acquired partial lipodystrophy.

KW - Acquired partial lipodystrophy

KW - IL-27

KW - MMP-28

KW - MMP-7

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Adult-onset acquired partial lipodystrophy accompanied by rheumatoid arthritis

Abstract

Keywords

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