Adult Onset of BRAFV600E-Mutated Langerhans Cell Histiocytosis with Cutaneous Involvement Successfully Diagnosed by Immunohistochemical Staining

Hisayuki Tono; Taku Fujimura; Aya Kakizaki; Sadanori Furudate; Masaya Ishibashi; Setsuya Aiba

doi:10.1159/000440643

Adult Onset of BRAF^V600E-Mutated Langerhans Cell Histiocytosis with Cutaneous Involvement Successfully Diagnosed by Immunohistochemical Staining

Hisayuki Tono, Taku Fujimura, Aya Kakizaki, Sadanori Furudate, Masaya Ishibashi, Setsuya Aiba

MED - Medical Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

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Abstract

Langerhans cell histiocytosis (LCH) is characterized by the clonal proliferation of Langerhans cells; it is categorized as a single-system disease with single or multifocal lesions, and as a multi-system disease with or without the risk of organ involvement. Although the skin is not categorized as a risk organ, the precise diagnosis of skin lesions is necessary to determine the protocol for the treatment of LCH. In this report, we describe a 28-year-old Japanese man with adult onset of BRAF^V600E-mutated LCH with cutaneous involvement successfully diagnosed by immunohistochemical staining. Our report suggests that immunohistochemical staining for the BRAF^V600E gene could be a diagnostic tool to determine the clinical type of LCH.

Original language	English
Pages (from-to)	237-240
Number of pages	4
Journal	Case Reports in Dermatology
Volume	7
Issue number	3
DOIs	https://doi.org/10.1159/000440643
Publication status	Published - 2015 Dec 1

Keywords

Adult onset of Langerhans cell histiocytosis
BRAF
Chemotherapy
Clinical type

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title = "Adult Onset of BRAFV600E-Mutated Langerhans Cell Histiocytosis with Cutaneous Involvement Successfully Diagnosed by Immunohistochemical Staining",

abstract = "Langerhans cell histiocytosis (LCH) is characterized by the clonal proliferation of Langerhans cells; it is categorized as a single-system disease with single or multifocal lesions, and as a multi-system disease with or without the risk of organ involvement. Although the skin is not categorized as a risk organ, the precise diagnosis of skin lesions is necessary to determine the protocol for the treatment of LCH. In this report, we describe a 28-year-old Japanese man with adult onset of BRAFV600E-mutated LCH with cutaneous involvement successfully diagnosed by immunohistochemical staining. Our report suggests that immunohistochemical staining for the BRAFV600E gene could be a diagnostic tool to determine the clinical type of LCH.",

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author = "Hisayuki Tono and Taku Fujimura and Aya Kakizaki and Sadanori Furudate and Masaya Ishibashi and Setsuya Aiba",

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T1 - Adult Onset of BRAFV600E-Mutated Langerhans Cell Histiocytosis with Cutaneous Involvement Successfully Diagnosed by Immunohistochemical Staining

AU - Tono, Hisayuki

AU - Fujimura, Taku

AU - Kakizaki, Aya

AU - Furudate, Sadanori

AU - Ishibashi, Masaya

AU - Aiba, Setsuya

PY - 2015/12/1

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N2 - Langerhans cell histiocytosis (LCH) is characterized by the clonal proliferation of Langerhans cells; it is categorized as a single-system disease with single or multifocal lesions, and as a multi-system disease with or without the risk of organ involvement. Although the skin is not categorized as a risk organ, the precise diagnosis of skin lesions is necessary to determine the protocol for the treatment of LCH. In this report, we describe a 28-year-old Japanese man with adult onset of BRAFV600E-mutated LCH with cutaneous involvement successfully diagnosed by immunohistochemical staining. Our report suggests that immunohistochemical staining for the BRAFV600E gene could be a diagnostic tool to determine the clinical type of LCH.

AB - Langerhans cell histiocytosis (LCH) is characterized by the clonal proliferation of Langerhans cells; it is categorized as a single-system disease with single or multifocal lesions, and as a multi-system disease with or without the risk of organ involvement. Although the skin is not categorized as a risk organ, the precise diagnosis of skin lesions is necessary to determine the protocol for the treatment of LCH. In this report, we describe a 28-year-old Japanese man with adult onset of BRAFV600E-mutated LCH with cutaneous involvement successfully diagnosed by immunohistochemical staining. Our report suggests that immunohistochemical staining for the BRAFV600E gene could be a diagnostic tool to determine the clinical type of LCH.

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KW - Chemotherapy

KW - Clinical type

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Adult Onset of BRAF^V600E-Mutated Langerhans Cell Histiocytosis with Cutaneous Involvement Successfully Diagnosed by Immunohistochemical Staining

Abstract

Keywords

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