TY - JOUR
T1 - Advanced glycation and lipoxidation end products
T2 - Reactive carbonyl compounds-related uraemic toxicity
AU - Miyata, Toshio
AU - Saito, Akira
AU - Kurokawa, Kiyoshi
AU - Van Ypersele De Strihou, Charles
PY - 2001
Y1 - 2001
N2 - Most studies on uraemic toxins have focused on disorders of enzymatic biochemistry. Recent studies to elucidate the pathogenesis of dialysis-related amyloidosis have provided new insights in progressive, irreversible protein modifications resulting from non-enzymatic biochemistry in uraemia. This paper focuses on two types of irreversible alterations of proteins: advanced glycation and lipoxidation. We investigate the causal role of various reactive carbonyl compounds (RCOs) accumulating in the serum, speculate on its clinical consequences, and discuss the therapeutic perspectives.
AB - Most studies on uraemic toxins have focused on disorders of enzymatic biochemistry. Recent studies to elucidate the pathogenesis of dialysis-related amyloidosis have provided new insights in progressive, irreversible protein modifications resulting from non-enzymatic biochemistry in uraemia. This paper focuses on two types of irreversible alterations of proteins: advanced glycation and lipoxidation. We investigate the causal role of various reactive carbonyl compounds (RCOs) accumulating in the serum, speculate on its clinical consequences, and discuss the therapeutic perspectives.
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U2 - 10.1093/ndt/16.suppl_4.8
DO - 10.1093/ndt/16.suppl_4.8
M3 - Article
C2 - 11402090
AN - SCOPUS:0034948769
SN - 0931-0509
VL - 16
SP - 8
EP - 11
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
IS - SUPPL. 4
ER -