Advanced glycation end products in patients with cerebral infarction

Yuko Ohnuki, Reiko Nagano, Shunya Takizawa, Shigeharu Takagi, Toshio Miyata

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Objective: Oxidative modification of carbohydrates and lipids enhances the formation of advanced glycation end products (AGEs), which are formed not only in hyperglycemia, but also in normoglycemia. In this study, we determined skin AGEs in patients with cerebral infarction. Patients and Methods: We non-invasively measured skin autofluorescence (AF) levels in patients with chronic cerebral infarction (CCI; n=95), patients with silent brain infarction (SBI; n=40), and age-matched controls (n=34), using an AGE Reader. Results: Skin AF levels in patients with CCI and SBI were significantly increased compared with those in the control group (2.06±0.38, 2.16±0.47 and 1.84±0.35, respectively). Angiotension receptor blocker (ARB) or statins had no significant effect on the level of advanced glycation in any of the groups. Conclusion: Our data suggest that increased formation of AGEs may be an indicator of oxidative stress, not only in diabetes and renal failure, but also in chronic cerebral ischemia.

Original languageEnglish
Pages (from-to)587-591
Number of pages5
JournalInternal Medicine
Issue number8
Publication statusPublished - 2009


  • Advanced glycation end products
  • AGE reader
  • Cerebral infarction
  • Oxidative stress


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