Advanced Invasive Extramammary Paget's Disease Concomitant with Cecal Cancer Possessing Rare Variant of TP53 Single Nucleotide Polymorphism

Yumi Kambayashi; Taku Fujimura; Kentaro Ohuchi; Hisayuki Tono; Yoshihiro Ishida; Atsushi Otsuka; Setsuya Aiba

doi:10.1159/000504339

Advanced Invasive Extramammary Paget's Disease Concomitant with Cecal Cancer Possessing Rare Variant of TP53 Single Nucleotide Polymorphism

Yumi Kambayashi, Taku Fujimura, Kentaro Ohuchi, Hisayuki Tono, Yoshihiro Ishida, Atsushi Otsuka, Setsuya Aiba

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Patients with invasive extramammary Paget's disease have an increased risk of secondary malignancy, mostly occurring colorectal carcinoma. TP53 is a regulator of apoptosis, cell cycle arrest, and DNA damage response pathways, and has been reported as one of the genetic biomarkers for colorectal carcinoma. In this report, we describe a case of advanced invasive EMPD concomitant with cecal cancer with a rare variant of TP53 single nucleotide polymorphism (rs121912665). To our knowledge, there is no English report that presents EMPD concomitant with cecal carcinoma.

Original language	English
Pages (from-to)	855-860
Number of pages	6
Journal	Case Reports in Oncology
Volume	12
Issue number	3
DOIs	https://doi.org/10.1159/000504339
Publication status	Published - 2019 Sept 1

Keywords

Cecal carcinoma
CK20
CK7
EMPD
Immunohistochemical staining
TP53 SNP

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000504339

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title = "Advanced Invasive Extramammary Paget's Disease Concomitant with Cecal Cancer Possessing Rare Variant of TP53 Single Nucleotide Polymorphism",

abstract = "Patients with invasive extramammary Paget's disease have an increased risk of secondary malignancy, mostly occurring colorectal carcinoma. TP53 is a regulator of apoptosis, cell cycle arrest, and DNA damage response pathways, and has been reported as one of the genetic biomarkers for colorectal carcinoma. In this report, we describe a case of advanced invasive EMPD concomitant with cecal cancer with a rare variant of TP53 single nucleotide polymorphism (rs121912665). To our knowledge, there is no English report that presents EMPD concomitant with cecal carcinoma.",

keywords = "Cecal carcinoma, CK20, CK7, EMPD, Immunohistochemical staining, TP53 SNP",

author = "Yumi Kambayashi and Taku Fujimura and Kentaro Ohuchi and Hisayuki Tono and Yoshihiro Ishida and Atsushi Otsuka and Setsuya Aiba",

note = "Funding Information: This study was supported in part by the Japan Agency for Medical Research and Development (19cm0106434h0002). Publisher Copyright: {\textcopyright} 2019 The Author(s). Published by S. Karger AG, Basel.",

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doi = "10.1159/000504339",

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T1 - Advanced Invasive Extramammary Paget's Disease Concomitant with Cecal Cancer Possessing Rare Variant of TP53 Single Nucleotide Polymorphism

AU - Kambayashi, Yumi

AU - Fujimura, Taku

AU - Ohuchi, Kentaro

AU - Tono, Hisayuki

AU - Ishida, Yoshihiro

AU - Otsuka, Atsushi

AU - Aiba, Setsuya

N1 - Funding Information: This study was supported in part by the Japan Agency for Medical Research and Development (19cm0106434h0002). Publisher Copyright: © 2019 The Author(s). Published by S. Karger AG, Basel.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Patients with invasive extramammary Paget's disease have an increased risk of secondary malignancy, mostly occurring colorectal carcinoma. TP53 is a regulator of apoptosis, cell cycle arrest, and DNA damage response pathways, and has been reported as one of the genetic biomarkers for colorectal carcinoma. In this report, we describe a case of advanced invasive EMPD concomitant with cecal cancer with a rare variant of TP53 single nucleotide polymorphism (rs121912665). To our knowledge, there is no English report that presents EMPD concomitant with cecal carcinoma.

AB - Patients with invasive extramammary Paget's disease have an increased risk of secondary malignancy, mostly occurring colorectal carcinoma. TP53 is a regulator of apoptosis, cell cycle arrest, and DNA damage response pathways, and has been reported as one of the genetic biomarkers for colorectal carcinoma. In this report, we describe a case of advanced invasive EMPD concomitant with cecal cancer with a rare variant of TP53 single nucleotide polymorphism (rs121912665). To our knowledge, there is no English report that presents EMPD concomitant with cecal carcinoma.

KW - Cecal carcinoma

KW - CK20

KW - CK7

KW - EMPD

KW - Immunohistochemical staining

KW - TP53 SNP

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JO - Case Reports in Oncology

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Advanced Invasive Extramammary Paget's Disease Concomitant with Cecal Cancer Possessing Rare Variant of TP53 Single Nucleotide Polymorphism

Abstract

Keywords

UN SDGs

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