TY - JOUR
T1 - Age-related brain atrophy and mental deterioration. A study with computed tomography
AU - Ito, M.
AU - Hatazawa, J.
AU - Yamaura, H.
AU - Matsuzawa, T.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - The relation of brain atrophy measured with computed tomography (CT) to mental deterioration on living people was studied. A newly improved technique for quantitative measurement of brain atrophy was developed. The pixels inside the head slices were divided into three parts; brain, skull, and cerebrospinal fluid according to their CT number. The volume of brain, CSF, and cranial cavity were calculated by counting the number of pixels of each tissue. Results from 130 normal brains showed that the CSF volume was constant at about 16 ml through 20-39 years old. After 40 years the mean CSF volume increased drasticaly and reached 71 ml in the seventies. The volume of the brain was standardized for comparison between different-sized heads (brain volume index: BVI). The mean BVI decreased with statistical significance after 40 years of age. Mental function of these persons were evaluated using Hasegawa's dementia rating scale for the elderly. Progression of brain atrophy accompanied loss of mental activities (p < 0.01).
AB - The relation of brain atrophy measured with computed tomography (CT) to mental deterioration on living people was studied. A newly improved technique for quantitative measurement of brain atrophy was developed. The pixels inside the head slices were divided into three parts; brain, skull, and cerebrospinal fluid according to their CT number. The volume of brain, CSF, and cranial cavity were calculated by counting the number of pixels of each tissue. Results from 130 normal brains showed that the CSF volume was constant at about 16 ml through 20-39 years old. After 40 years the mean CSF volume increased drasticaly and reached 71 ml in the seventies. The volume of the brain was standardized for comparison between different-sized heads (brain volume index: BVI). The mean BVI decreased with statistical significance after 40 years of age. Mental function of these persons were evaluated using Hasegawa's dementia rating scale for the elderly. Progression of brain atrophy accompanied loss of mental activities (p < 0.01).
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U2 - 10.1259/0007-1285-54-641-384
DO - 10.1259/0007-1285-54-641-384
M3 - Article
C2 - 7237008
AN - SCOPUS:0019507852
SN - 0007-1285
VL - 54
SP - 384
EP - 390
JO - British Journal of Radiology
JF - British Journal of Radiology
IS - 641
ER -