Age-related change of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide levels in normal human red blood cells

Teruo Miyazawa; Toshihide Suzuki; Kenshiro Fujimoto; Mikio Kinoshita

doi:10.1016/0047-6374(95)01687-2

Age-related change of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide levels in normal human red blood cells

Teruo Miyazawa, Toshihide Suzuki, Kenshiro Fujimoto, Mikio Kinoshita

New Industry Creation Hatchery Center (NICHe)

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

The age-related occurrence of phosphatidylcholine hydroperoxide (PCOOH) and phosphatidylethanolamine hydroperoxide (PEOOH) in normal human red blood cells (RBC) was confirmed by using chemiluminescence detection-high performance liquid chromatography (CL-HPLC). The concentration (mean ± S.D.) for the healthy young adult (22-27 of age, n = 20) was 93 ± 17 pmol PCOOH and 121 ± 20 pmol PEOOH/ml packed RBC, while for the aged adult (56-92 of age, n = 20) the peroxide content was significantly higher, 162 ± 52 pmol PCOOH and 186 ± 40 pmol PEOOH/ml packed RBC. These results indicate that oxidative stress occurs constantly on RBC, even in normal humans, and that the susceptivity significantly increases with age.

Original language	English
Pages (from-to)	145-150
Number of pages	6
Journal	Mechanisms of Ageing and Development
Volume	86
Issue number	3
DOIs	https://doi.org/10.1016/0047-6374(95)01687-2
Publication status	Published - 1996 Mar 29

Keywords

Aging
Phosphatidylcholine hydroperoxide
Phosphatidylethanolamine hydroperoxide
Red blood cells

ASJC Scopus subject areas

Ageing
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0047-6374(95)01687-2

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title = "Age-related change of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide levels in normal human red blood cells",

abstract = "The age-related occurrence of phosphatidylcholine hydroperoxide (PCOOH) and phosphatidylethanolamine hydroperoxide (PEOOH) in normal human red blood cells (RBC) was confirmed by using chemiluminescence detection-high performance liquid chromatography (CL-HPLC). The concentration (mean ± S.D.) for the healthy young adult (22-27 of age, n = 20) was 93 ± 17 pmol PCOOH and 121 ± 20 pmol PEOOH/ml packed RBC, while for the aged adult (56-92 of age, n = 20) the peroxide content was significantly higher, 162 ± 52 pmol PCOOH and 186 ± 40 pmol PEOOH/ml packed RBC. These results indicate that oxidative stress occurs constantly on RBC, even in normal humans, and that the susceptivity significantly increases with age.",

keywords = "Aging, Phosphatidylcholine hydroperoxide, Phosphatidylethanolamine hydroperoxide, Red blood cells",

author = "Teruo Miyazawa and Toshihide Suzuki and Kenshiro Fujimoto and Mikio Kinoshita",

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doi = "10.1016/0047-6374(95)01687-2",

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T1 - Age-related change of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide levels in normal human red blood cells

AU - Miyazawa, Teruo

AU - Suzuki, Toshihide

AU - Fujimoto, Kenshiro

AU - Kinoshita, Mikio

PY - 1996/3/29

Y1 - 1996/3/29

N2 - The age-related occurrence of phosphatidylcholine hydroperoxide (PCOOH) and phosphatidylethanolamine hydroperoxide (PEOOH) in normal human red blood cells (RBC) was confirmed by using chemiluminescence detection-high performance liquid chromatography (CL-HPLC). The concentration (mean ± S.D.) for the healthy young adult (22-27 of age, n = 20) was 93 ± 17 pmol PCOOH and 121 ± 20 pmol PEOOH/ml packed RBC, while for the aged adult (56-92 of age, n = 20) the peroxide content was significantly higher, 162 ± 52 pmol PCOOH and 186 ± 40 pmol PEOOH/ml packed RBC. These results indicate that oxidative stress occurs constantly on RBC, even in normal humans, and that the susceptivity significantly increases with age.

AB - The age-related occurrence of phosphatidylcholine hydroperoxide (PCOOH) and phosphatidylethanolamine hydroperoxide (PEOOH) in normal human red blood cells (RBC) was confirmed by using chemiluminescence detection-high performance liquid chromatography (CL-HPLC). The concentration (mean ± S.D.) for the healthy young adult (22-27 of age, n = 20) was 93 ± 17 pmol PCOOH and 121 ± 20 pmol PEOOH/ml packed RBC, while for the aged adult (56-92 of age, n = 20) the peroxide content was significantly higher, 162 ± 52 pmol PCOOH and 186 ± 40 pmol PEOOH/ml packed RBC. These results indicate that oxidative stress occurs constantly on RBC, even in normal humans, and that the susceptivity significantly increases with age.

KW - Aging

KW - Phosphatidylcholine hydroperoxide

KW - Phosphatidylethanolamine hydroperoxide

KW - Red blood cells

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SN - 0047-6374

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JO - Mechanisms of Ageing and Development

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ER -

Age-related change of phosphatidylcholine hydroperoxide and phosphatidylethanolamine hydroperoxide levels in normal human red blood cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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