Aggressive B-cell lymphoma with dual surface immunoglobulin light-chain expression

Tohru Fujiwara, Kenichi Ishizawa, Katsura Kohata, Joji Yamamoto, Minami F. Yamada, Junichi Kameoka, Ryo Ichinohasama, Hideo Harigae

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Dual surface immunoglobulin light-chain expression in B-cell malignant neoplasm is a rare event, and has been predominantly reported in chronic lymphocytic leukemia. Herein, we report a case of aggressive B-cell lymphoma with κ/λ-dual surface immunoglobulin light-chain expression of a 69-year-old woman. The lymphoma cells were positive for CD5, CD19, CD20, HLA-DR, Igκ and Igλ. Southern blot analysis confirmed rearranged bands for both light chains with a monoclonal heavy chain rearrangement. She was treated with a combination of rituximab and CHOP regimen, but died of the progressive disease. To our knowledge, this is the first case of aggressive B-cell lymphoma showing dual κ/λ expression; the possible mechanisms of abnormal light chain expression are discussed.

Original languageEnglish
Pages (from-to)1458-1461
Number of pages4
JournalInternal Medicine
Issue number17
Publication statusPublished - 2007 Sept 3


  • κ/λ dual expression
  • Aggressive B-cell lymphoma
  • Gene rearrangement


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