Aldosterone-Producing Cell Clusters in Normal and Pathological States

Kei Omata, Scott A. Tomlins, William E. Rainey

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)


Primary aldosteronism (PA) significantly increases the risk of cardiovascular complications, and early diagnosis and targeted treatment based on its pathophysiology is warranted. Next-generation sequencing (NGS) has revealed recurrent somatic mutations in aldosterone-driving genes in aldosterone-producing adenoma (APA). By applying CYP11B2 (aldosterone synthase) immunohistochemistry and NGS to adrenal glands from normal subjects and PA patients, we and others have shown that CYP11B2-positive cells make small clusters, termed aldosterone-producing cell clusters (APCC), beneath the adrenal capsule, and that APCC harbor somatic mutations in genes mutated in APA. We have shown that APCC are increased in CT-negative PA adrenals, while others showed potential progression from APCC to micro APA through mutations. These results suggest that APCC are a key factor for understanding the origin of PA, and further investigation on the relation between APCC and PA is highly needed.

Original languageEnglish
Pages (from-to)951-956
Number of pages6
JournalHormone and Metabolic Research
Issue number12
Publication statusPublished - 2017 Dec 1


  • aldosterone-producing cell clusters
  • next-generation sequencing
  • primary aldosteronism


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