Algorithm for the treatment of schizophrenia in Japan

M. Sato, N. Nakane, M. Hayashida, Y. Koshino, H. Uchimura, T. Tsutsumi, T. Koyama, I. Kusumi, K. Akiyama, H. Saito, T. Saijo, C. Ito, Y. Kubota, T. Nishikawa, Y. Kuroda, T. Hamamura, Y. Fujiwara, T. Higuchi, S. Yamawaki

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Evidence-based psychopharmacological algorithms for the treatment of patients with schizophrenia have been developed in many countries in the last decade. While it would be of interest to consider a common algorithm based on international consensus, algorithms and information on antipsychotics available in each country are limited. Inspired by the algorithm generated by the International Psychopharmacology Algorithm (IPA) Project, this algorithm for the treatment of schizophrenia has been developed by the Japan Psychopharmacology Algorithm (JPA) Project. New antipsychotics, such as clozapine, olanzapine and quetiapine, are excluded from this algorithm, being currently unavailable in Japan. In the end there was no essential difference between the algorithms for the treatment of acute schizophrenic episodes. However, combined use of antipsychotics appears to be more common in Japan and the adjunctive use of L-DOPS or thyrotropin-releasing hormone is included in the JPA algorithm for the treatment of drug-refractory schizophrenia.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalInternational Journal of Psychiatry in Clinical Practice
Issue number4
Publication statusPublished - 1999 Dec


  • Acute schizophrenic episode
  • International Psychopharmacology Algorithm
  • Japan Psychomarcology Algorithm Project
  • Therapy-resistant schizophrenia
  • Treatment algorithm


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