Aligning collagen fibers by cyclic mechanical stretch for efficiently muscle cell actuator

Keiji Seki; Masahiro Shimizu; Kota Miyasaka; Toshihiko Ogura; Koh Hosoda

doi:10.1109/ROBIO.2016.7866488

Aligning collagen fibers by cyclic mechanical stretch for efficiently muscle cell actuator

Keiji Seki, Masahiro Shimizu, Kota Miyasaka, Toshihiko Ogura, Koh Hosoda

IDAC - Division of Brain Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

Muscle cell actuators are composed of skeletal muscle cells and collagen intercellular matrix. Muscle cells adhere to collagen fibers and contraction along with the direction of collagen fiber. Collagen fibers in a muscle cell actuator transmit contraction force of each muscle cells along longitudinal direction. In order to improve contraction force of muscle cell actuators, it is very important to align collagen fibers. In this study, we aim to achieve alignment of collagen fibers in the actuator. We developed the automatic culture system which apply cyclic stretch to muscle cell actuators. We estimated the structure the actuator by using a scanning electron microscope and fluorescent observation. And we confirmed that cyclic stretch induced alignment of collagen fibers in the muscle cell actuators.

Original language	English
Title of host publication	2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1197-1202
Number of pages	6
ISBN (Electronic)	9781509043644
DOIs	https://doi.org/10.1109/ROBIO.2016.7866488
Publication status	Published - 2016
Event	2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016 - Qingdao, China Duration: 2016 Dec 3 → 2016 Dec 7

Publication series

Name	2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016

Conference

Conference	2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016
Country/Territory	China
City	Qingdao
Period	16/12/3 → 16/12/7

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10.1109/ROBIO.2016.7866488

Cite this

Seki, K., Shimizu, M., Miyasaka, K., Ogura, T., & Hosoda, K. (2016). Aligning collagen fibers by cyclic mechanical stretch for efficiently muscle cell actuator. In 2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016 (pp. 1197-1202). Article 7866488 (2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ROBIO.2016.7866488

Seki, Keiji ; Shimizu, Masahiro ; Miyasaka, Kota et al. / Aligning collagen fibers by cyclic mechanical stretch for efficiently muscle cell actuator. 2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 1197-1202 (2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016).

@inproceedings{022d7a35a931419692fd499bbcc9af5f,

title = "Aligning collagen fibers by cyclic mechanical stretch for efficiently muscle cell actuator",

abstract = "Muscle cell actuators are composed of skeletal muscle cells and collagen intercellular matrix. Muscle cells adhere to collagen fibers and contraction along with the direction of collagen fiber. Collagen fibers in a muscle cell actuator transmit contraction force of each muscle cells along longitudinal direction. In order to improve contraction force of muscle cell actuators, it is very important to align collagen fibers. In this study, we aim to achieve alignment of collagen fibers in the actuator. We developed the automatic culture system which apply cyclic stretch to muscle cell actuators. We estimated the structure the actuator by using a scanning electron microscope and fluorescent observation. And we confirmed that cyclic stretch induced alignment of collagen fibers in the muscle cell actuators.",

author = "Keiji Seki and Masahiro Shimizu and Kota Miyasaka and Toshihiko Ogura and Koh Hosoda",

note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016 ; Conference date: 03-12-2016 Through 07-12-2016",

year = "2016",

doi = "10.1109/ROBIO.2016.7866488",

language = "English",

series = "2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "1197--1202",

booktitle = "2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016",

address = "United States",

}

Seki, K, Shimizu, M, Miyasaka, K, Ogura, T & Hosoda, K 2016, Aligning collagen fibers by cyclic mechanical stretch for efficiently muscle cell actuator. in 2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016., 7866488, 2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016, Institute of Electrical and Electronics Engineers Inc., pp. 1197-1202, 2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016, Qingdao, China, 16/12/3. https://doi.org/10.1109/ROBIO.2016.7866488

Aligning collagen fibers by cyclic mechanical stretch for efficiently muscle cell actuator. / Seki, Keiji; Shimizu, Masahiro; Miyasaka, Kota et al.
2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016. Institute of Electrical and Electronics Engineers Inc., 2016. p. 1197-1202 7866488 (2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Aligning collagen fibers by cyclic mechanical stretch for efficiently muscle cell actuator

AU - Seki, Keiji

AU - Shimizu, Masahiro

AU - Miyasaka, Kota

AU - Ogura, Toshihiko

AU - Hosoda, Koh

PY - 2016

Y1 - 2016

N2 - Muscle cell actuators are composed of skeletal muscle cells and collagen intercellular matrix. Muscle cells adhere to collagen fibers and contraction along with the direction of collagen fiber. Collagen fibers in a muscle cell actuator transmit contraction force of each muscle cells along longitudinal direction. In order to improve contraction force of muscle cell actuators, it is very important to align collagen fibers. In this study, we aim to achieve alignment of collagen fibers in the actuator. We developed the automatic culture system which apply cyclic stretch to muscle cell actuators. We estimated the structure the actuator by using a scanning electron microscope and fluorescent observation. And we confirmed that cyclic stretch induced alignment of collagen fibers in the muscle cell actuators.

AB - Muscle cell actuators are composed of skeletal muscle cells and collagen intercellular matrix. Muscle cells adhere to collagen fibers and contraction along with the direction of collagen fiber. Collagen fibers in a muscle cell actuator transmit contraction force of each muscle cells along longitudinal direction. In order to improve contraction force of muscle cell actuators, it is very important to align collagen fibers. In this study, we aim to achieve alignment of collagen fibers in the actuator. We developed the automatic culture system which apply cyclic stretch to muscle cell actuators. We estimated the structure the actuator by using a scanning electron microscope and fluorescent observation. And we confirmed that cyclic stretch induced alignment of collagen fibers in the muscle cell actuators.

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BT - 2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016

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Seki K, Shimizu M, Miyasaka K, Ogura T, Hosoda K. Aligning collagen fibers by cyclic mechanical stretch for efficiently muscle cell actuator. In 2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016. Institute of Electrical and Electronics Engineers Inc. 2016. p. 1197-1202. 7866488. (2016 IEEE International Conference on Robotics and Biomimetics, ROBIO 2016). doi: 10.1109/ROBIO.2016.7866488

Aligning collagen fibers by cyclic mechanical stretch for efficiently muscle cell actuator

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