TY - GEN
T1 - ALL-in-one microfluidic device for microvascular connection
AU - Owaki, Hirofumi
AU - Masuda, Taisuke
AU - Kawahara, Tomohiro
AU - Miyasaka, Kota
AU - Ogura, Toshihiko
AU - Arai, Fumihito
PY - 2013
Y1 - 2013
N2 - We newly propose a microfluidic device with multiple functions for simple microvascular connection. By using this microfluidic device with suction mechanism, we can operate the blood vessels in a single device for assisting the microvascular connection procedure such as fixing the position of the blood vessels, expanding the diameter of the blood vessels, and pouring the adhesion and drugs. We have succeeded in connecting the microcardiovascular of the extracted chicken embryonic heart to artificial mictotubes in a shorter time than the manual operation such as suturing. We have also succeeded in constructing the biological simulator that can observe a living organ continuously while circulating the culture medium through the inside of the heart. Finally, we showed the prototype platform of the evaluating the migration of the cells at the connection part between the extracted tissue from living organism and the assembled tissue structure.
AB - We newly propose a microfluidic device with multiple functions for simple microvascular connection. By using this microfluidic device with suction mechanism, we can operate the blood vessels in a single device for assisting the microvascular connection procedure such as fixing the position of the blood vessels, expanding the diameter of the blood vessels, and pouring the adhesion and drugs. We have succeeded in connecting the microcardiovascular of the extracted chicken embryonic heart to artificial mictotubes in a shorter time than the manual operation such as suturing. We have also succeeded in constructing the biological simulator that can observe a living organ continuously while circulating the culture medium through the inside of the heart. Finally, we showed the prototype platform of the evaluating the migration of the cells at the connection part between the extracted tissue from living organism and the assembled tissue structure.
UR - http://www.scopus.com/inward/record.url?scp=84875479280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875479280&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2013.6474437
DO - 10.1109/MEMSYS.2013.6474437
M3 - Conference contribution
AN - SCOPUS:84875479280
SN - 9781467356558
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 1081
EP - 1084
BT - IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
T2 - IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
Y2 - 20 January 2013 through 24 January 2013
ER -