Allogeneic Hematopoietic Stem Cell Transplantation for Leukocyte Adhesion Deficiency

Yasuo Horikoshi; Katsutsugu Umeda; Kohsuke Imai; Hiromasa Yabe; Yoji Sasahara; Kenichiro Watanabe; Yukiyasu Ozawa; Yoshiko Hashii; Hidemitsu Kurosawa; Shigeaki Nonoyama; Tomohiro Morio

doi:10.1097/MPH.0000000000001028

Allogeneic Hematopoietic Stem Cell Transplantation for Leukocyte Adhesion Deficiency

Yasuo Horikoshi, Katsutsugu Umeda, Kohsuke Imai, Hiromasa Yabe, Yoji Sasahara, Kenichiro Watanabe, Yukiyasu Ozawa, Yoshiko Hashii, Hidemitsu Kurosawa, Shigeaki Nonoyama, Tomohiro Morio

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) was retrospectively analyzed in 6 patients with leukocyte adhesion deficiency. Of 3 patients transplanted with myeloablative conditioning, 2 patients had complete chimerism and 1 patient had mixed chimerism. By contrast, all 3 patients transplanted with reduced-intensity conditioning (RIC) had mixed chimerism, one of whom progressed to secondary graft failure. All patients with low-level mixed chimerism and secondary graft failure were rescued by donor lymphocyte infusion or a second HSCT. RIC-HSCT is feasible for leukocyte adhesion deficiency, although further refinement/modification of conditioning is required to achieve higher donor chimerism levels.

Original language	English
Pages (from-to)	137-140
Number of pages	4
Journal	Journal of Pediatric Hematology/Oncology
Volume	40
Issue number	2
DOIs	https://doi.org/10.1097/MPH.0000000000001028
Publication status	Published - 2018

Keywords

donor lymphocyte infusion
hematopoietic stem cell transplantation
leukocyte adhesion deficiency
reduced-intensity conditioning

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10.1097/MPH.0000000000001028

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title = "Allogeneic Hematopoietic Stem Cell Transplantation for Leukocyte Adhesion Deficiency",

abstract = "The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) was retrospectively analyzed in 6 patients with leukocyte adhesion deficiency. Of 3 patients transplanted with myeloablative conditioning, 2 patients had complete chimerism and 1 patient had mixed chimerism. By contrast, all 3 patients transplanted with reduced-intensity conditioning (RIC) had mixed chimerism, one of whom progressed to secondary graft failure. All patients with low-level mixed chimerism and secondary graft failure were rescued by donor lymphocyte infusion or a second HSCT. RIC-HSCT is feasible for leukocyte adhesion deficiency, although further refinement/modification of conditioning is required to achieve higher donor chimerism levels.",

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author = "Yasuo Horikoshi and Katsutsugu Umeda and Kohsuke Imai and Hiromasa Yabe and Yoji Sasahara and Kenichiro Watanabe and Yukiyasu Ozawa and Yoshiko Hashii and Hidemitsu Kurosawa and Shigeaki Nonoyama and Tomohiro Morio",

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T1 - Allogeneic Hematopoietic Stem Cell Transplantation for Leukocyte Adhesion Deficiency

AU - Horikoshi, Yasuo

AU - Umeda, Katsutsugu

AU - Imai, Kohsuke

AU - Yabe, Hiromasa

AU - Sasahara, Yoji

AU - Watanabe, Kenichiro

AU - Ozawa, Yukiyasu

AU - Hashii, Yoshiko

AU - Kurosawa, Hidemitsu

AU - Nonoyama, Shigeaki

AU - Morio, Tomohiro

PY - 2018

Y1 - 2018

N2 - The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) was retrospectively analyzed in 6 patients with leukocyte adhesion deficiency. Of 3 patients transplanted with myeloablative conditioning, 2 patients had complete chimerism and 1 patient had mixed chimerism. By contrast, all 3 patients transplanted with reduced-intensity conditioning (RIC) had mixed chimerism, one of whom progressed to secondary graft failure. All patients with low-level mixed chimerism and secondary graft failure were rescued by donor lymphocyte infusion or a second HSCT. RIC-HSCT is feasible for leukocyte adhesion deficiency, although further refinement/modification of conditioning is required to achieve higher donor chimerism levels.

AB - The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) was retrospectively analyzed in 6 patients with leukocyte adhesion deficiency. Of 3 patients transplanted with myeloablative conditioning, 2 patients had complete chimerism and 1 patient had mixed chimerism. By contrast, all 3 patients transplanted with reduced-intensity conditioning (RIC) had mixed chimerism, one of whom progressed to secondary graft failure. All patients with low-level mixed chimerism and secondary graft failure were rescued by donor lymphocyte infusion or a second HSCT. RIC-HSCT is feasible for leukocyte adhesion deficiency, although further refinement/modification of conditioning is required to achieve higher donor chimerism levels.

KW - donor lymphocyte infusion

KW - hematopoietic stem cell transplantation

KW - leukocyte adhesion deficiency

KW - reduced-intensity conditioning

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ER -

Allogeneic Hematopoietic Stem Cell Transplantation for Leukocyte Adhesion Deficiency

Abstract

Keywords

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