TY - JOUR
T1 - Alpha-adducin Gly460Trp polymorphism is associated with low renin hypertension in younger subjects in the Ohasama study
AU - Sugimoto, Ken
AU - Hozawa, Atsushi
AU - Katsuya, Tomohiro
AU - Matsubara, Mitsunobu
AU - Ohkubo, Takayoshi
AU - Tsuji, Ichiro
AU - Motone, Masaharu
AU - Higaki, Jitsuo
AU - Hisamachi, Shigeru
AU - Imai, Yutaka
AU - Ogihara, Toshio
PY - 2002/9
Y1 - 2002/9
N2 - Background: The Gly460Trp polymorphism of the alpha-adducin gene (ADD-1) has been examined as a candidate gene for essential hypertension with salt sensitivity in the Caucasian population. However, we failed to detect a positive association between the Gly460Trp polymorphism of ADD-1 and hypertension in a small series of Japanese subjects. Objective: To examine the precise association between the Gly460Trp polymorphism of ADD-1 and blood pressure (BP), we carried out an association study using a Japanese population: the Ohasama Study. Design: Subjects (n = 1490) were recruited from participants in the Ohasama Study, which is a cohort in a rural community of northern Japan. Methods: DNA was extracted from the buffy coat of the participants who gave informed consent for genetic analysis, and the Gly460Trp polymorphism of ADD-1 was determined by the TaqMan polymerase chain reaction method. Various BP values (casual BP, ambulatory BP and home BP) were measured in the Ohasama study. We used the mean values of these BP measurements for analysis. Results: The frequencies of genotypes in the Ohasama population were 23% Gly/Gly, 49% Gly/Trp, and 28% Trp/Trp. In the baseline characteristics, age, sex, body mass index, frequency of diabetes and hyperlipidemia were significantly different between hypertensive or normotensive subjects. In total subjects, all BP values were not different among ADD-1 genotypes. In the younger subjects (<60 years old) with low plasma renin activity (< 1.0 ng/ml per h), however, ambulatory BP and home BP were significantly higher in the subjects with the Gly/Trp or Trp/Trp genotypes of ADD-1 polymorphism than in those with the Gly/Gly genotype. In the same population, the frequency of the Gly/Trp or Trp/Trp genotypes of ADD-1 was significantly higher in hypertensives than in normotensives (83 versus 72%, X12 = 4.04, P<0.05; odds ratio, 2.12; 95% confidence interval, 1.02-4.68). Conclusions: These findings suggest the possibility that the Gly460Trp polymorphism of ADD-1 is associated with low renin hypertension.
AB - Background: The Gly460Trp polymorphism of the alpha-adducin gene (ADD-1) has been examined as a candidate gene for essential hypertension with salt sensitivity in the Caucasian population. However, we failed to detect a positive association between the Gly460Trp polymorphism of ADD-1 and hypertension in a small series of Japanese subjects. Objective: To examine the precise association between the Gly460Trp polymorphism of ADD-1 and blood pressure (BP), we carried out an association study using a Japanese population: the Ohasama Study. Design: Subjects (n = 1490) were recruited from participants in the Ohasama Study, which is a cohort in a rural community of northern Japan. Methods: DNA was extracted from the buffy coat of the participants who gave informed consent for genetic analysis, and the Gly460Trp polymorphism of ADD-1 was determined by the TaqMan polymerase chain reaction method. Various BP values (casual BP, ambulatory BP and home BP) were measured in the Ohasama study. We used the mean values of these BP measurements for analysis. Results: The frequencies of genotypes in the Ohasama population were 23% Gly/Gly, 49% Gly/Trp, and 28% Trp/Trp. In the baseline characteristics, age, sex, body mass index, frequency of diabetes and hyperlipidemia were significantly different between hypertensive or normotensive subjects. In total subjects, all BP values were not different among ADD-1 genotypes. In the younger subjects (<60 years old) with low plasma renin activity (< 1.0 ng/ml per h), however, ambulatory BP and home BP were significantly higher in the subjects with the Gly/Trp or Trp/Trp genotypes of ADD-1 polymorphism than in those with the Gly/Gly genotype. In the same population, the frequency of the Gly/Trp or Trp/Trp genotypes of ADD-1 was significantly higher in hypertensives than in normotensives (83 versus 72%, X12 = 4.04, P<0.05; odds ratio, 2.12; 95% confidence interval, 1.02-4.68). Conclusions: These findings suggest the possibility that the Gly460Trp polymorphism of ADD-1 is associated with low renin hypertension.
KW - Alpha-adducin (ADD-1) gene
KW - Genetics
KW - Hypertension
KW - Single nucleotide polymorphism
KW - TaqMan polymerase chain reaction
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U2 - 10.1097/00004872-200209000-00022
DO - 10.1097/00004872-200209000-00022
M3 - Article
C2 - 12195119
AN - SCOPUS:18544382859
SN - 0263-6352
VL - 20
SP - 1779
EP - 1784
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 9
ER -
