Alteration of telomerase activity in ovarian cancer after chemotherapy

Masakuni Takahashi; Junzo Kigawa; Tetsuro Oishi; Hiroaki Itamochi; Muneaki Shimada; Shinya Sato; Shunji Kamazawa; Ryouji Akeshima; Naoki Terakawa

doi:10.1159/000010247

Alteration of telomerase activity in ovarian cancer after chemotherapy

Masakuni Takahashi, Junzo Kigawa, Tetsuro Oishi, Hiroaki Itamochi, Muneaki Shimada, Shinya Sato, Shunji Kamazawa, Ryouji Akeshima, Naoki Terakawa

Advanced Research Center for Innovations in Next-Generation Medicine (INGEM)

Tottori University

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

To elucidate the relationship between telomerase activity and chemosensitivity in epithelial ovarian cancer, telomerase activity and telomere length (TRF) were examined before and after chemotherapy. Of 21 patients, 9 patients responded to chemotherapy and 12 did not. The positivity of telomerase activity did not significantly differ between responders and nonresponders. There were no differences in the mean length and the distribution of TRF between the two groups. Those distributions became narrow after chemotherapy in both groups. Seven nonresponders (58.3%) exhibited an increase in telomerase activity after chemotherapy but none of the responders showed an increase in activity. Telomerase activity may relate to chemosensitivity in epithelial ovarian cancer. (C) 2000 S. Karger AG, Basel.

Original language	English
Pages (from-to)	204-208
Number of pages	5
Journal	Gynecologic and Obstetric Investigation
Volume	49
Issue number	3
DOIs	https://doi.org/10.1159/000010247
Publication status	Published - 2000

Keywords

Chemotherapy
Ovarian cancer
Telomerase activity
Telomere

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000010247

Cite this

@article{860863c4badf45078d09def6ca7d4ef7,

title = "Alteration of telomerase activity in ovarian cancer after chemotherapy",

abstract = "To elucidate the relationship between telomerase activity and chemosensitivity in epithelial ovarian cancer, telomerase activity and telomere length (TRF) were examined before and after chemotherapy. Of 21 patients, 9 patients responded to chemotherapy and 12 did not. The positivity of telomerase activity did not significantly differ between responders and nonresponders. There were no differences in the mean length and the distribution of TRF between the two groups. Those distributions became narrow after chemotherapy in both groups. Seven nonresponders (58.3%) exhibited an increase in telomerase activity after chemotherapy but none of the responders showed an increase in activity. Telomerase activity may relate to chemosensitivity in epithelial ovarian cancer. (C) 2000 S. Karger AG, Basel.",

keywords = "Chemotherapy, Ovarian cancer, Telomerase activity, Telomere",

author = "Masakuni Takahashi and Junzo Kigawa and Tetsuro Oishi and Hiroaki Itamochi and Muneaki Shimada and Shinya Sato and Shunji Kamazawa and Ryouji Akeshima and Naoki Terakawa",

year = "2000",

doi = "10.1159/000010247",

language = "English",

volume = "49",

pages = "204--208",

journal = "Gynecologic and Obstetric Investigation",

issn = "0378-7346",

publisher = "S. Karger AG",

number = "3",

}

TY - JOUR

T1 - Alteration of telomerase activity in ovarian cancer after chemotherapy

AU - Takahashi, Masakuni

AU - Kigawa, Junzo

AU - Oishi, Tetsuro

AU - Itamochi, Hiroaki

AU - Shimada, Muneaki

AU - Sato, Shinya

AU - Kamazawa, Shunji

AU - Akeshima, Ryouji

AU - Terakawa, Naoki

PY - 2000

Y1 - 2000

N2 - To elucidate the relationship between telomerase activity and chemosensitivity in epithelial ovarian cancer, telomerase activity and telomere length (TRF) were examined before and after chemotherapy. Of 21 patients, 9 patients responded to chemotherapy and 12 did not. The positivity of telomerase activity did not significantly differ between responders and nonresponders. There were no differences in the mean length and the distribution of TRF between the two groups. Those distributions became narrow after chemotherapy in both groups. Seven nonresponders (58.3%) exhibited an increase in telomerase activity after chemotherapy but none of the responders showed an increase in activity. Telomerase activity may relate to chemosensitivity in epithelial ovarian cancer. (C) 2000 S. Karger AG, Basel.

AB - To elucidate the relationship between telomerase activity and chemosensitivity in epithelial ovarian cancer, telomerase activity and telomere length (TRF) were examined before and after chemotherapy. Of 21 patients, 9 patients responded to chemotherapy and 12 did not. The positivity of telomerase activity did not significantly differ between responders and nonresponders. There were no differences in the mean length and the distribution of TRF between the two groups. Those distributions became narrow after chemotherapy in both groups. Seven nonresponders (58.3%) exhibited an increase in telomerase activity after chemotherapy but none of the responders showed an increase in activity. Telomerase activity may relate to chemosensitivity in epithelial ovarian cancer. (C) 2000 S. Karger AG, Basel.

KW - Chemotherapy

KW - Ovarian cancer

KW - Telomerase activity

KW - Telomere

UR - http://www.scopus.com/inward/record.url?scp=0034119093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034119093&partnerID=8YFLogxK

U2 - 10.1159/000010247

DO - 10.1159/000010247

M3 - Article

C2 - 10729763

AN - SCOPUS:0034119093

SN - 0378-7346

VL - 49

SP - 204

EP - 208

JO - Gynecologic and Obstetric Investigation

JF - Gynecologic and Obstetric Investigation

IS - 3

ER -

Alteration of telomerase activity in ovarian cancer after chemotherapy

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this