TY - GEN
T1 - Altering the microtubule kinesin nanomechanics in the presence of metallic ions
AU - Bhattacharyya, Sanjib
AU - Kim, Kyongwan
AU - Nakazawa, Hikaru
AU - Umetsu, Mitsuo
AU - Teizer, Winfried
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/11/21
Y1 - 2016/11/21
N2 - Microtubules play an important role in intraneuronal communication. A barrier to microtubule mediated neuronal transport can initiate dementia. The nanoscale modeling of these biological events is expected to be useful for healthcare applications and auxiliary biosensor based diagnostics. Here, we report a model system by using an in vitro bio-motility assay to predict events related to dementia at excess metal ion concentration. We demonstrate how metal ions (calcium, iron, zinc) at pathophysiologically relevant concentrations have the ability to affect the gliding motion of microtubules on kinesin. The addition of the neurotransmitter (acetyl choline) has no apparent effect on MT gliding. Therefore, the reagents that can stabilize the bio-motility system have potential to regulate dementia.
AB - Microtubules play an important role in intraneuronal communication. A barrier to microtubule mediated neuronal transport can initiate dementia. The nanoscale modeling of these biological events is expected to be useful for healthcare applications and auxiliary biosensor based diagnostics. Here, we report a model system by using an in vitro bio-motility assay to predict events related to dementia at excess metal ion concentration. We demonstrate how metal ions (calcium, iron, zinc) at pathophysiologically relevant concentrations have the ability to affect the gliding motion of microtubules on kinesin. The addition of the neurotransmitter (acetyl choline) has no apparent effect on MT gliding. Therefore, the reagents that can stabilize the bio-motility system have potential to regulate dementia.
UR - http://www.scopus.com/inward/record.url?scp=85006913810&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006913810&partnerID=8YFLogxK
U2 - 10.1109/NANO.2016.7751410
DO - 10.1109/NANO.2016.7751410
M3 - Conference contribution
AN - SCOPUS:85006913810
T3 - 16th International Conference on Nanotechnology - IEEE NANO 2016
SP - 79
EP - 81
BT - 16th International Conference on Nanotechnology - IEEE NANO 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 16th IEEE International Conference on Nanotechnology - IEEE NANO 2016
Y2 - 22 August 2016 through 25 August 2016
ER -