Aluminium toxicity in the rat liver and brain

S. Yumoto, H. Ohashi, H. Nagai, S. Kakimi, A. Ishikawa, K. Kobayashi, Y. Ogawa, K. Ishii

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


To investigate the etiology of Alzheimer's disease, we examined the brain and liver tissue uptake of aluminium 5-75 days after aluminium injection into healthy rats. Ten days after the last injection, Al was detected in the brain and the brain cell nuclei by particle-induced X-ray emission (PIXE) analysis. Al was also demonstrated in the liver and the liver cell nuclei by PIXE analysis and electron energy loss spectrometry (EELS). The morphological changes of the rat brain examined 75 days after the injection were similar to those which have been reportedly observed in the brain of patients with Alzheimer's disease. These results support the theory that Alzheimer's disease is caused by irreversible accumulation of aluminium in the brain, as well as in the nuclei of brain cells.

Original languageEnglish
Pages (from-to)188-190
Number of pages3
JournalNuclear Inst. and Methods in Physics Research, B
Issue number1-4
Publication statusPublished - 1993 Apr 3
Externally publishedYes

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Instrumentation


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