TY - JOUR
T1 - Aluminium toxicity in the rat liver and brain
AU - Yumoto, S.
AU - Ohashi, H.
AU - Nagai, H.
AU - Kakimi, S.
AU - Ishikawa, A.
AU - Kobayashi, K.
AU - Ogawa, Y.
AU - Ishii, K.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1993/4/3
Y1 - 1993/4/3
N2 - To investigate the etiology of Alzheimer's disease, we examined the brain and liver tissue uptake of aluminium 5-75 days after aluminium injection into healthy rats. Ten days after the last injection, Al was detected in the brain and the brain cell nuclei by particle-induced X-ray emission (PIXE) analysis. Al was also demonstrated in the liver and the liver cell nuclei by PIXE analysis and electron energy loss spectrometry (EELS). The morphological changes of the rat brain examined 75 days after the injection were similar to those which have been reportedly observed in the brain of patients with Alzheimer's disease. These results support the theory that Alzheimer's disease is caused by irreversible accumulation of aluminium in the brain, as well as in the nuclei of brain cells.
AB - To investigate the etiology of Alzheimer's disease, we examined the brain and liver tissue uptake of aluminium 5-75 days after aluminium injection into healthy rats. Ten days after the last injection, Al was detected in the brain and the brain cell nuclei by particle-induced X-ray emission (PIXE) analysis. Al was also demonstrated in the liver and the liver cell nuclei by PIXE analysis and electron energy loss spectrometry (EELS). The morphological changes of the rat brain examined 75 days after the injection were similar to those which have been reportedly observed in the brain of patients with Alzheimer's disease. These results support the theory that Alzheimer's disease is caused by irreversible accumulation of aluminium in the brain, as well as in the nuclei of brain cells.
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U2 - 10.1016/0168-583X(93)95640-Q
DO - 10.1016/0168-583X(93)95640-Q
M3 - Article
AN - SCOPUS:0009034585
SN - 0168-583X
VL - 75
SP - 188
EP - 190
JO - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
JF - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
IS - 1-4
ER -