Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions

Tetsuya Ohgami; Tetsuyuki Kitamoto; Jun Tateishi

doi:10.1016/0304-3940(92)90651-M

Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions

Tetsuya Ohgami, Tetsuyuki Kitamoto, Jun Tateishi

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

By using a monoclonal antibody and polyclonal antibodies to human β amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus with Hallervorden-Spatz disease as well as in or around brain abscesses. The axonal swellings were not immunolabeled with β protein. These results implied that APP accumulated in spheroids regardless of β protein depositions.

Original language	English
Pages (from-to)	75-78
Number of pages	4
Journal	Neuroscience Letters
Volume	136
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(92)90651-M
Publication status	Published - 1992 Feb 17
Externally published	Yes

Keywords

Alzheimer's disease
Axonal swelling
Hallervorden-Spatz disease
Immunohistochemistry
Infarction
Spheroid
β Amyloid precursor protein
β Amyloid protein

ASJC Scopus subject areas

Neuroscience(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3940(92)90651-M

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title = "Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions",

abstract = "By using a monoclonal antibody and polyclonal antibodies to human β amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus with Hallervorden-Spatz disease as well as in or around brain abscesses. The axonal swellings were not immunolabeled with β protein. These results implied that APP accumulated in spheroids regardless of β protein depositions.",

keywords = "Alzheimer's disease, Axonal swelling, Hallervorden-Spatz disease, Immunohistochemistry, Infarction, Spheroid, β Amyloid precursor protein, β Amyloid protein",

author = "Tetsuya Ohgami and Tetsuyuki Kitamoto and Jun Tateishi",

note = "Funding Information: The authors thank Dr. K. Beyreuther and Dr. A. Wei-denmann for their encouragements, K. Hatanaka for her excellent technical assistance and B. Quinn for his comments on the manuscript. This work was supported by grants from the Ministry of Education, Science and Culture (02454245, 03454171), the Ministry of Health and Welfare, the Science and Technology Agency and the Foundation for Advancement of Clinical Medicine.",

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doi = "10.1016/0304-3940(92)90651-M",

language = "English",

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journal = "Neuroscience Letters",

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T1 - Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions

AU - Ohgami, Tetsuya

AU - Kitamoto, Tetsuyuki

AU - Tateishi, Jun

N1 - Funding Information: The authors thank Dr. K. Beyreuther and Dr. A. Wei-denmann for their encouragements, K. Hatanaka for her excellent technical assistance and B. Quinn for his comments on the manuscript. This work was supported by grants from the Ministry of Education, Science and Culture (02454245, 03454171), the Ministry of Health and Welfare, the Science and Technology Agency and the Foundation for Advancement of Clinical Medicine.

PY - 1992/2/17

Y1 - 1992/2/17

N2 - By using a monoclonal antibody and polyclonal antibodies to human β amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus with Hallervorden-Spatz disease as well as in or around brain abscesses. The axonal swellings were not immunolabeled with β protein. These results implied that APP accumulated in spheroids regardless of β protein depositions.

AB - By using a monoclonal antibody and polyclonal antibodies to human β amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus with Hallervorden-Spatz disease as well as in or around brain abscesses. The axonal swellings were not immunolabeled with β protein. These results implied that APP accumulated in spheroids regardless of β protein depositions.

KW - Alzheimer's disease

KW - Axonal swelling

KW - Hallervorden-Spatz disease

KW - Immunohistochemistry

KW - Infarction

KW - Spheroid

KW - β Amyloid precursor protein

KW - β Amyloid protein

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DO - 10.1016/0304-3940(92)90651-M

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SN - 0304-3940

VL - 136

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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