TY - JOUR
T1 - AlzPathway
T2 - A comprehensive map of signaling pathways of Alzheimer's disease
AU - Mizuno, Satoshi
AU - Iijima, Risa
AU - Ogishima, Soichi
AU - Kikuchi, Masataka
AU - Matsuoka, Yukiko
AU - Ghosh, Samik
AU - Miyamoto, Tadashi
AU - Miyashita, Akinori
AU - Kuwano, Ryozo
AU - Tanaka, Hiroshi
N1 - Funding Information:
The authors are grateful for the helpful comments of an editor and anonymous referees. We thank Dr. Takeshi Fukuhara for critical discussion on AlzPathway. Funding: This work was supported by Grant-in-Aid for Scientific Research (22700311) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan. The Payao system is supported by Okinawa Institute of Science and Technology (http://www.oist.jp).
PY - 2012/5/30
Y1 - 2012/5/30
N2 - Background: Alzheimer's disease (AD) is the most common cause of dementia among the elderly. To clarify pathogenesis of AD, thousands of reports have been accumulating. However, knowledge of signaling pathways in the field of AD has not been compiled as a database before.Description: Here, we have constructed a publicly available pathway map called " AlzPathway" that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 review articles related to AD, and have built an AD pathway map using CellDesigner. AlzPathway is currently composed of 1347 molecules and 1070 reactions in neuron, brain blood barrier, presynaptic, postsynaptic, astrocyte, and microglial cells and their cellular localizations. AlzPathway is available as both the SBML (Systems Biology Markup Language) map for CellDesigner and the high resolution image map. AlzPathway is also available as a web service (online map) based on Payao system, a community-based, collaborative web service platform for pathway model curation, enabling continuous updates by AD researchers.Conclusions: AlzPathway is the first comprehensive map of intra, inter and extra cellular AD signaling pathways which can enable mechanistic deciphering of AD pathogenesis. The AlzPathway map is accessible at http://alzpathway.org/.
AB - Background: Alzheimer's disease (AD) is the most common cause of dementia among the elderly. To clarify pathogenesis of AD, thousands of reports have been accumulating. However, knowledge of signaling pathways in the field of AD has not been compiled as a database before.Description: Here, we have constructed a publicly available pathway map called " AlzPathway" that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 review articles related to AD, and have built an AD pathway map using CellDesigner. AlzPathway is currently composed of 1347 molecules and 1070 reactions in neuron, brain blood barrier, presynaptic, postsynaptic, astrocyte, and microglial cells and their cellular localizations. AlzPathway is available as both the SBML (Systems Biology Markup Language) map for CellDesigner and the high resolution image map. AlzPathway is also available as a web service (online map) based on Payao system, a community-based, collaborative web service platform for pathway model curation, enabling continuous updates by AD researchers.Conclusions: AlzPathway is the first comprehensive map of intra, inter and extra cellular AD signaling pathways which can enable mechanistic deciphering of AD pathogenesis. The AlzPathway map is accessible at http://alzpathway.org/.
UR - http://www.scopus.com/inward/record.url?scp=84861547140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861547140&partnerID=8YFLogxK
U2 - 10.1186/1752-0509-6-52
DO - 10.1186/1752-0509-6-52
M3 - Article
C2 - 22647208
AN - SCOPUS:84861547140
SN - 1752-0509
VL - 6
JO - BMC Systems Biology
JF - BMC Systems Biology
M1 - 52
ER -