@article{52f6e512768a4c789be364d2a069678f,
title = "Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes",
abstract = "Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.",
keywords = "Amadori-glycated phosphatidylethanolamine, Curcumin, Glucose transporter, Glycolipid, Liposome, Maillard reaction product",
author = "Taiki Miyazawa and Reina Kamiyoshihara and Naoki Shimizu and Takahiro Harigae and Yurika Otoki and Junya Ito and Shunji Kato and Teruo Miyazawa and Kiyotaka Nakagawa",
note = "Funding Information: We thank Mayuko Itaya (Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan) for her assistance in the preparation of the manuscript. Funding Information: Authors{\textquoteright} contributions. T.M., R.K., N.S., Y.O., J.I. and S.K. performed all the experiments, characterization and analysis of the data. T.M., R.K. and N.S. participated in the manuscript writing. K.N. and T.M. participated in the study design and data interpretation. T.M. and R.K. contributed equally to this work. All authors gave final approval for publication. Competing interests. We declare we have no competing interests. Funding. This work was supported by the Grants-in-Aid for Scientific Research (KAKENHI (15K14725 and 25252025)). T.M. was supported by JSPS fellowship (DC2, 12J07486). Acknowledgements. We thank Mayuko Itaya (Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan) for her assistance in the preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018 The Authors.",
year = "2018",
month = feb,
doi = "10.1098/rsos.171249",
language = "English",
volume = "5",
journal = "Royal Society Open Science",
issn = "2054-5703",
publisher = "The Royal Society",
number = "2",
}