Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells

Takahiro Eitsuka; Kiyotaka Nakagawa; Yuichi Ono; Naoto Tatewaki; Hiroshi Nishida; Tadao Kurata; Naoki Shoji; Teruo Miyazawa

doi:10.1016/j.febslet.2012.06.027

Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells

Takahiro Eitsuka, Kiyotaka Nakagawa, Yuichi Ono, Naoto Tatewaki, Hiroshi Nishida, Tadao Kurata, Naoki Shoji, Teruo Miyazawa

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Several lines of experimental data have highlighted a key role of Amadori-glycated phosphatidylethanolamine (Amadori-PE) in the development of diabetic complications. Recent epidemiological studies suggest that diabetes mellitus could be a risk factor for some cancers. A characteristic of cancer cells is their immortal phenotype, and the enzyme telomerase contributes to the infinite replicative potential of cancer cells. The purpose of this study was to obtain new information about the effect of Amadori-PE on the regulation of telomerase in PANC-1 human pancreatic carcinoma cells. Amadori-PE enhanced cellular telomerase in a time- and dose-dependent manner by up-regulating hTERT expression through induction of c-myc. These results provide experimental evidence for a novel role of Amadori-PE in linking diabetes and cancer. Crown

Original language	English
Pages (from-to)	2542-2547
Number of pages	6
Journal	FEBS Letters
Volume	586
Issue number	16
DOIs	https://doi.org/10.1016/j.febslet.2012.06.027
Publication status	Published - 2012 Jul 30

Keywords

Amadori product
Cancer
Diabetes mellitus
Glycation
Telomerase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2012.06.027

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title = "Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells",

abstract = "Several lines of experimental data have highlighted a key role of Amadori-glycated phosphatidylethanolamine (Amadori-PE) in the development of diabetic complications. Recent epidemiological studies suggest that diabetes mellitus could be a risk factor for some cancers. A characteristic of cancer cells is their immortal phenotype, and the enzyme telomerase contributes to the infinite replicative potential of cancer cells. The purpose of this study was to obtain new information about the effect of Amadori-PE on the regulation of telomerase in PANC-1 human pancreatic carcinoma cells. Amadori-PE enhanced cellular telomerase in a time- and dose-dependent manner by up-regulating hTERT expression through induction of c-myc. These results provide experimental evidence for a novel role of Amadori-PE in linking diabetes and cancer. Crown",

keywords = "Amadori product, Cancer, Diabetes mellitus, Glycation, Telomerase",

author = "Takahiro Eitsuka and Kiyotaka Nakagawa and Yuichi Ono and Naoto Tatewaki and Hiroshi Nishida and Tadao Kurata and Naoki Shoji and Teruo Miyazawa",

year = "2012",

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doi = "10.1016/j.febslet.2012.06.027",

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T1 - Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells

AU - Eitsuka, Takahiro

AU - Nakagawa, Kiyotaka

AU - Ono, Yuichi

AU - Tatewaki, Naoto

AU - Nishida, Hiroshi

AU - Kurata, Tadao

AU - Shoji, Naoki

AU - Miyazawa, Teruo

PY - 2012/7/30

Y1 - 2012/7/30

N2 - Several lines of experimental data have highlighted a key role of Amadori-glycated phosphatidylethanolamine (Amadori-PE) in the development of diabetic complications. Recent epidemiological studies suggest that diabetes mellitus could be a risk factor for some cancers. A characteristic of cancer cells is their immortal phenotype, and the enzyme telomerase contributes to the infinite replicative potential of cancer cells. The purpose of this study was to obtain new information about the effect of Amadori-PE on the regulation of telomerase in PANC-1 human pancreatic carcinoma cells. Amadori-PE enhanced cellular telomerase in a time- and dose-dependent manner by up-regulating hTERT expression through induction of c-myc. These results provide experimental evidence for a novel role of Amadori-PE in linking diabetes and cancer. Crown

AB - Several lines of experimental data have highlighted a key role of Amadori-glycated phosphatidylethanolamine (Amadori-PE) in the development of diabetic complications. Recent epidemiological studies suggest that diabetes mellitus could be a risk factor for some cancers. A characteristic of cancer cells is their immortal phenotype, and the enzyme telomerase contributes to the infinite replicative potential of cancer cells. The purpose of this study was to obtain new information about the effect of Amadori-PE on the regulation of telomerase in PANC-1 human pancreatic carcinoma cells. Amadori-PE enhanced cellular telomerase in a time- and dose-dependent manner by up-regulating hTERT expression through induction of c-myc. These results provide experimental evidence for a novel role of Amadori-PE in linking diabetes and cancer. Crown

KW - Amadori product

KW - Cancer

KW - Diabetes mellitus

KW - Glycation

KW - Telomerase

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JF - FEBS Letters

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ER -

Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells

Abstract

Keywords

UN SDGs

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