@article{f3a391dac62b430c94f0ecb7c2742959,
title = "Amide bond formation of sialic acid in oligosaccharide without protecting group",
abstract = "– With the aim of preparing glycan-linked antibody-drug conjugates, we investigated the feasibility of amide bond formation at the carboxylic acid of sialic acid in a protection-free oligosaccharide. The use of a phosphonium salt-based reagent, PyBOP, gave the desired compound. Bio-orthogonal functional groups were conjugated at the carboxylic acid site of sialic acid in glycans.",
author = "Shino Manabe and Junpei Abe and Yukishige Ito",
note = "Funding Information: We would like to thank Fushimi Pharmaceutical Co. Ltd. for disialyloctasaccharide. S. M. was supported by a MEXT/JSPS KAKENHI (Grant No. 24590041) and Japan Agency of Medical Research and Development (17cm0106220h0002). We would like to thank Ms. Akemi Takahashi for technical assistance. Publisher Copyright: {\textcopyright} 2018 The Japan Institute of Heterocyclic Chemistry",
year = "2018",
doi = "10.3987/COM-18-S(T)69",
language = "English",
volume = "97",
pages = "1203--1209",
journal = "Heterocycles",
issn = "0385-5414",
publisher = "Japan Institute of Heterocyclic Chemistry",
number = "2",
}