Amyloid β induces adhesion of erythrocytes to endothelial cells and affects endothelial viability and functionality

Kiyotaka Nakagawa; Takehiro Kiko; Satoko Kuriwada; Taiki Miyazawa; Fumiko Kimura; Teruo Miyazawa

doi:10.1271/bbb.110318

Amyloid β induces adhesion of erythrocytes to endothelial cells and affects endothelial viability and functionality

Kiyotaka Nakagawa, Takehiro Kiko, Satoko Kuriwada, Taiki Miyazawa, Fumiko Kimura, Teruo Miyazawa

Tohoku University

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

It has been suggested that amyloid β-peptide (A β) might mediate the adhesion of erythrocytes to the endothelium which could disrupt the properties of endothelial cells. We provide evidence here that Aβactually induced the binding of erythrocytes to endothelial cells and decreased endothelial viability, perhaps by the generation of oxidative and inflammatory stress. These changes are likely to contribute to the pathogenesis of Alzheimer's disease.

Original language	English
Pages (from-to)	2030-2033
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	75
Issue number	10
DOIs	https://doi.org/10.1271/bbb.110318
Publication status	Published - 2011

Keywords

Alzheimer's disease
Amyloid β-peptide
Endothelial cell
Red blood cell

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10.1271/bbb.110318

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abstract = "It has been suggested that amyloid β-peptide (A β) might mediate the adhesion of erythrocytes to the endothelium which could disrupt the properties of endothelial cells. We provide evidence here that Aβactually induced the binding of erythrocytes to endothelial cells and decreased endothelial viability, perhaps by the generation of oxidative and inflammatory stress. These changes are likely to contribute to the pathogenesis of Alzheimer's disease.",

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author = "Kiyotaka Nakagawa and Takehiro Kiko and Satoko Kuriwada and Taiki Miyazawa and Fumiko Kimura and Teruo Miyazawa",

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AU - Kiko, Takehiro

AU - Kuriwada, Satoko

AU - Miyazawa, Taiki

AU - Kimura, Fumiko

AU - Miyazawa, Teruo

N1 - Funding Information: This work was partly supported by Kakenhi (S) (20228002 to T. M.) of JSPS, Japan.

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KW - Amyloid β-peptide

KW - Endothelial cell

KW - Red blood cell

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Amyloid β induces adhesion of erythrocytes to endothelial cells and affects endothelial viability and functionality

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Keywords

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