An Analysis Scheme for 3D Visualization of Positron Emitting Radioisotopes Using Positron Emission Mammography System

Md Rafiqul Islam; Mehrdad Shahmohammadi Beni; Shigeki Ito; Shinichi Gotoh; Taiga Yamaya; Hiroshi Watabe

doi:10.3390/app12020823

An Analysis Scheme for 3D Visualization of Positron Emitting Radioisotopes Using Positron Emission Mammography System

Md Rafiqul Islam, Mehrdad Shahmohammadi Beni, Shigeki Ito, Shinichi Gotoh, Taiga Yamaya, Hiroshi Watabe

Cyclotron and Radioisotope Center (CYRIC)

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Proton range monitoring and verification is important to enhance the effectiveness of treatment by ensuring that the correct dose is delivered to the correct location. Upon proton irradiation, different positron emitting radioisotopes are produced by the inelastic nuclear interactions of protons with the target elements. Recently, it was reported that the¹⁶ O(p,2p2n)¹³ N reaction has a relatively low threshold energy, and it could be potentially used for proton range verification. In the present work, we have proposed an analysis scheme (i.e., algorithm) for the extraction and three-dimensional visualization of positron emitting radioisotopes. The proposed step-by-step analysis scheme was tested using our own experimentally obtained dynamic data from a positron emission mammography (PEM) system (our developed PEMGRAPH system). The experimental irradiation was performed using an azimuthally varying field (AVF) cyclotron with a 80 MeV monoenergetic pencil-like beam. The 3D visualization showed promising results for proton-induced radioisotope distribution. The proposed scheme and developed tools would be useful for the extraction and 3D visualization of positron emitting radioisotopes and in turn for proton range monitoring and verification.

Original language	English
Article number	823
Journal	Applied Sciences (Switzerland)
Volume	12
Issue number	2
DOIs	https://doi.org/10.3390/app12020823
Publication status	Published - 2022 Jan 1

Keywords

PEM
Positron emitters
Proton range monitoring
Proton therapy
Spectral analysis

ASJC Scopus subject areas

Materials Science(all)
Instrumentation
Engineering(all)
Process Chemistry and Technology
Computer Science Applications
Fluid Flow and Transfer Processes

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10.3390/app12020823

Cite this

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title = "An Analysis Scheme for 3D Visualization of Positron Emitting Radioisotopes Using Positron Emission Mammography System",

abstract = "Proton range monitoring and verification is important to enhance the effectiveness of treatment by ensuring that the correct dose is delivered to the correct location. Upon proton irradiation, different positron emitting radioisotopes are produced by the inelastic nuclear interactions of protons with the target elements. Recently, it was reported that the16 O(p,2p2n)13 N reaction has a relatively low threshold energy, and it could be potentially used for proton range verification. In the present work, we have proposed an analysis scheme (i.e., algorithm) for the extraction and three-dimensional visualization of positron emitting radioisotopes. The proposed step-by-step analysis scheme was tested using our own experimentally obtained dynamic data from a positron emission mammography (PEM) system (our developed PEMGRAPH system). The experimental irradiation was performed using an azimuthally varying field (AVF) cyclotron with a 80 MeV monoenergetic pencil-like beam. The 3D visualization showed promising results for proton-induced radioisotope distribution. The proposed scheme and developed tools would be useful for the extraction and 3D visualization of positron emitting radioisotopes and in turn for proton range monitoring and verification.",

keywords = "PEM, Positron emitters, Proton range monitoring, Proton therapy, Spectral analysis",

author = "Islam, {Md Rafiqul} and Beni, {Mehrdad Shahmohammadi} and Shigeki Ito and Shinichi Gotoh and Taiga Yamaya and Hiroshi Watabe",

note = "Funding Information: Funding: This research work was funded by Japan Agency for Medical Research and Development (AMED) under Grant Number 20he2202004h0402 and Ministry of Education, Culture, Sports, Science and Technology (MEXT) under the grant number 21F21103. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Islam, Md Rafiqul

AU - Beni, Mehrdad Shahmohammadi

AU - Ito, Shigeki

AU - Gotoh, Shinichi

AU - Yamaya, Taiga

AU - Watabe, Hiroshi

N1 - Funding Information: Funding: This research work was funded by Japan Agency for Medical Research and Development (AMED) under Grant Number 20he2202004h0402 and Ministry of Education, Culture, Sports, Science and Technology (MEXT) under the grant number 21F21103. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Proton range monitoring and verification is important to enhance the effectiveness of treatment by ensuring that the correct dose is delivered to the correct location. Upon proton irradiation, different positron emitting radioisotopes are produced by the inelastic nuclear interactions of protons with the target elements. Recently, it was reported that the16 O(p,2p2n)13 N reaction has a relatively low threshold energy, and it could be potentially used for proton range verification. In the present work, we have proposed an analysis scheme (i.e., algorithm) for the extraction and three-dimensional visualization of positron emitting radioisotopes. The proposed step-by-step analysis scheme was tested using our own experimentally obtained dynamic data from a positron emission mammography (PEM) system (our developed PEMGRAPH system). The experimental irradiation was performed using an azimuthally varying field (AVF) cyclotron with a 80 MeV monoenergetic pencil-like beam. The 3D visualization showed promising results for proton-induced radioisotope distribution. The proposed scheme and developed tools would be useful for the extraction and 3D visualization of positron emitting radioisotopes and in turn for proton range monitoring and verification.

AB - Proton range monitoring and verification is important to enhance the effectiveness of treatment by ensuring that the correct dose is delivered to the correct location. Upon proton irradiation, different positron emitting radioisotopes are produced by the inelastic nuclear interactions of protons with the target elements. Recently, it was reported that the16 O(p,2p2n)13 N reaction has a relatively low threshold energy, and it could be potentially used for proton range verification. In the present work, we have proposed an analysis scheme (i.e., algorithm) for the extraction and three-dimensional visualization of positron emitting radioisotopes. The proposed step-by-step analysis scheme was tested using our own experimentally obtained dynamic data from a positron emission mammography (PEM) system (our developed PEMGRAPH system). The experimental irradiation was performed using an azimuthally varying field (AVF) cyclotron with a 80 MeV monoenergetic pencil-like beam. The 3D visualization showed promising results for proton-induced radioisotope distribution. The proposed scheme and developed tools would be useful for the extraction and 3D visualization of positron emitting radioisotopes and in turn for proton range monitoring and verification.

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KW - Proton range monitoring

KW - Proton therapy

KW - Spectral analysis

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An Analysis Scheme for 3D Visualization of Positron Emitting Radioisotopes Using Positron Emission Mammography System

Abstract

Keywords

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