An anti-c-Fms antibody inhibits orthodontic tooth movement

H. Kitaura, M. Yoshimatsu, Y. Fujimura, T. Eguchi, H. Kohara, A. Yamaguchi, N. Yoshida

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Orthodontic force induces osteoclastogenesis in vivo. It has recently been reported that administration of an antibody against the macrophage-colony- stimulating factor (M-CSF) receptor c-Fms blocks osteoclastogenesis and bone erosion induced by tumor necrosis factor-α (TNF-α) administration. This study aimed to examine the effect of an anti-c-Fms antibody on mechanical loading-induced osteoclastogenesis and osteolysis in an orthodontic tooth movement model in mice. Using TNF receptor 1- and 2-deficient mice, we showed that orthodontic tooth movement was mediated by TNF-α. We injected anti-c-Fms antibody daily into a local site, for 12 days, during mechanical loading. The anti-c-Fms antibody significantly inhibited orthodontic tooth movement, markedly reduced the number of osteoclasts in vivo, and inhibited TNF-α-induced osteoclastogenesis in vitro. These findings suggest that M-CSF plays an important role in mechanical loading-induced osteoclastogenesis and bone resorption during orthodontic tooth movement mediated by TNF-α.

Original languageEnglish
Pages (from-to)396-400
Number of pages5
JournalJournal of Dental Research
Issue number4
Publication statusPublished - 2008 Apr


  • c-fms
  • Mouse
  • Orthodontics
  • Osteoclast
  • TNF-α


Dive into the research topics of 'An anti-c-Fms antibody inhibits orthodontic tooth movement'. Together they form a unique fingerprint.

Cite this