An efficient and regioselective iodination of electron-rich aromatic compounds using N-chlorosuccinimide and sodium iodide

Takuya Yamamoto; Kozo Toyota; Noboru Morita

doi:10.1016/j.tetlet.2009.12.125

An efficient and regioselective iodination of electron-rich aromatic compounds using N-chlorosuccinimide and sodium iodide

Takuya Yamamoto, Kozo Toyota, Noboru Morita

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

An efficient and regioselective method for iodination of electron-rich aromatic compounds was found using N-chlorosuccinimide and sodium iodide in AcOH with short reaction times. This method is also applicable to non-benzenoid aromatic or heteroaromatic compounds.

Original language	English
Pages (from-to)	1364-1366
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	10
DOIs	https://doi.org/10.1016/j.tetlet.2009.12.125
Publication status	Published - 2010 Mar 10

Keywords

Aromatic compounds
Electrophilic substitution
Iodination
Thiophenes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2009.12.125

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title = "An efficient and regioselective iodination of electron-rich aromatic compounds using N-chlorosuccinimide and sodium iodide",

abstract = "An efficient and regioselective method for iodination of electron-rich aromatic compounds was found using N-chlorosuccinimide and sodium iodide in AcOH with short reaction times. This method is also applicable to non-benzenoid aromatic or heteroaromatic compounds.",

keywords = "Aromatic compounds, Electrophilic substitution, Iodination, Thiophenes",

author = "Takuya Yamamoto and Kozo Toyota and Noboru Morita",

note = "Funding Information: This work was supported in part by the Grants-in-Aid for Scientific Research (No. 20550030 ) from the Ministry of Education, Culture, Sports, Science and Technology .",

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T1 - An efficient and regioselective iodination of electron-rich aromatic compounds using N-chlorosuccinimide and sodium iodide

AU - Yamamoto, Takuya

AU - Toyota, Kozo

AU - Morita, Noboru

N1 - Funding Information: This work was supported in part by the Grants-in-Aid for Scientific Research (No. 20550030 ) from the Ministry of Education, Culture, Sports, Science and Technology .

PY - 2010/3/10

Y1 - 2010/3/10

N2 - An efficient and regioselective method for iodination of electron-rich aromatic compounds was found using N-chlorosuccinimide and sodium iodide in AcOH with short reaction times. This method is also applicable to non-benzenoid aromatic or heteroaromatic compounds.

AB - An efficient and regioselective method for iodination of electron-rich aromatic compounds was found using N-chlorosuccinimide and sodium iodide in AcOH with short reaction times. This method is also applicable to non-benzenoid aromatic or heteroaromatic compounds.

KW - Aromatic compounds

KW - Electrophilic substitution

KW - Iodination

KW - Thiophenes

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EP - 1366

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 10

ER -

An efficient and regioselective iodination of electron-rich aromatic compounds using N-chlorosuccinimide and sodium iodide

Abstract

Keywords

ASJC Scopus subject areas

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