TY - JOUR
T1 - An efficient, one‐pot synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐glucopyranose (N‐[18F]fluoroacetyl‐D‐glucosamine), potential diagnostic imaging agent
AU - Tada, Masao
AU - Oikawa, Atsushi
AU - Iwata, Ren
AU - Fujiwara, Takehiko
AU - Kubota, Kazuo
AU - Matsuzawa, Taiju
AU - Sugiyama, Hiroshi
AU - Ido, Tatsuo
AU - Ishiwata, Kiichi
AU - Sato, Tachio
PY - 1989/11
Y1 - 1989/11
N2 - A rapid, one‐pot synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐glucopyranose (N‐[18F]fluoroacetyl‐D‐glucosamine) (1) starting from [18F]fluoride and ethyl bromoacetate is described. The synthesis was accomplished by a combination of halogen exchange, alkaline hydrolysis, and condensation. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total synthesis time, the radiochemical yield, and purity of (1) are ca. 90 min, ca. 9.1%, and >98%, respectively. Sugar (1) showed the diagnostic tumor‐imaging activity.
AB - A rapid, one‐pot synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐glucopyranose (N‐[18F]fluoroacetyl‐D‐glucosamine) (1) starting from [18F]fluoride and ethyl bromoacetate is described. The synthesis was accomplished by a combination of halogen exchange, alkaline hydrolysis, and condensation. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total synthesis time, the radiochemical yield, and purity of (1) are ca. 90 min, ca. 9.1%, and >98%, respectively. Sugar (1) showed the diagnostic tumor‐imaging activity.
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U2 - 10.1002/jlcr.2580271111
DO - 10.1002/jlcr.2580271111
M3 - Article
AN - SCOPUS:0024452592
SN - 0362-4803
VL - 27
SP - 1317
EP - 1324
JO - Journal of Labelled Compounds and Radiopharmaceuticals
JF - Journal of Labelled Compounds and Radiopharmaceuticals
IS - 11
ER -