An enzyme logic bioprotonic transducer

Takeo Miyake, Erik E. Josberger, Scott Keene, Yingxin Deng, Marco Rolandi

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Translating ionic currents into measureable electronic signals is essential for the integration of bioelectronic devices with biological systems. We demonstrate the use of a Pd/PdHx electrode as a bioprotonic transducer that connects H+ currents in solution into an electronic signal. This transducer exploits the reversible formation of PdHx in solution according to PdH虠Pd + H+ + e-, and the dependence of this formation on solution pH and applied potential. We integrate the protonic transducer with glucose dehydrogenase as an enzymatic and gate for glucose and NAD+. PdHx formation and associated electronic current monitors the output drop in pH, thus transducing a biological function into a measurable electronic output.

Original languageEnglish
Article number014906
JournalAPL Materials
Issue number1
Publication statusPublished - 2015 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)


Dive into the research topics of 'An enzyme logic bioprotonic transducer'. Together they form a unique fingerprint.

Cite this